Document Detail

Effects of pre-adaptation conditions and ambient room lighting on the multifocal ERG.
MedLine Citation:
PMID:  12152799     Owner:  NLM     Status:  MEDLINE    
The purpose of the study was to evaluate the effects of pre-adaptation and ambient room luminance on the multifocal ERG (mfERG). We recorded mfERGs on 18 normal subjects (average age 32) using a VERIS system, with either 61 or 103 stimulus hexagons. mfERGs were recorded sequentially under different conditions of pre-adaptation and room lighting. Changing pre-adaptation conditions between darkness for 20 min, or light at 1.43 log cd/m2 for 10 min, had essentially no effect on the mfERG, regardless of ambient room lighting. However, mfERG parameters were sensitive to the level of ambient room lighting during the recordings. As room luminance was increased from darkness, there was a gradual attenuation of N1 and P1 amplitudes both centrally and peripherally that approached 25% reduction at 1.6 log cd/m2, and a decrease in P1 time-to-peak. These effects were greatest in the blind spot. The mfERG is largely independent of pre-adaptation conditions, but waveform amplitudes and times-to-peak diminish with increasing ambient room luminance. The exaggerated attenuation of signals in the blind spot with room lighting suggests that mfERGs recorded in the dark are contaminated by light scattered to dark-adapted peripheral retina. The most stable mfERG recording condition appears to be a fully lighted room (1.6 log cd/m2).
Aimee V Chappelow; Michael F Marmor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Documenta ophthalmologica. Advances in ophthalmology     Volume:  105     ISSN:  0012-4486     ISO Abbreviation:  Doc Ophthalmol     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-08-02     Completed Date:  2003-01-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370667     Medline TA:  Doc Ophthalmol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  23-31     Citation Subset:  IM    
Stanford University, California, USA.
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MeSH Terms
Adaptation, Ocular / physiology*
Electroretinography / methods*
Middle Aged
Retina / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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