| Effects of prazosin and phentolamine on arterial pressure, heart rate, and renin activity: evidence in the conscious rat for the functional significance of the presynaptic alpha-receptor. | |
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MedLine Citation:
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PMID: 94406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the functional significance of the presynaptic alpha-adrenergic receptor, to stimulus-induced norepinephrine release. The effects of prazosin and phentolamine, alpha-adrenergic receptor antagonists with different in vitro selectivities for the presynaptic alpha-receptor, on mean arterial pressure and serum renin activity were determined in the conscious rat. Both drugs resulted in dose-related reductions in mean arterial pressure and dose-related increase in heart rate and serum renin activity. However, consistent with the greater selectivity of prazosin for the postsynaptic alpha-receptor, a given reduction in arterial pressure was associated with a lesser increment in heart rate and serum renin activity after prazosin than after the nonselective agent phentolamine. The differential effects of these agents on heart rate and serum renin activity are consistent with different degrees of blockade of a functionally significant presynaptic alpha-receptor. |
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Authors:
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R M Graham; W A Pettinger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 1 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1979 Sep-Oct |
Date Detail:
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Created Date: 1980-06-25 Completed Date: 1980-06-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 497-502 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Dose-Response Relationship, Drug Heart Rate / drug effects* Male Phentolamine / pharmacology* Prazosin / pharmacology* Quinazolines / pharmacology* Rats Receptors, Adrenergic / drug effects* Receptors, Adrenergic, alpha / drug effects* Renin / blood* |
| Chemical | |
Reg. No./Substance:
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0/Quinazolines; 0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 19216-56-9/Prazosin; 50-60-2/Phentolamine; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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