Document Detail


Effects of prazosin and phentolamine on arterial pressure, heart rate, and renin activity: evidence in the conscious rat for the functional significance of the presynaptic alpha-receptor.
MedLine Citation:
PMID:  94406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the functional significance of the presynaptic alpha-adrenergic receptor, to stimulus-induced norepinephrine release. The effects of prazosin and phentolamine, alpha-adrenergic receptor antagonists with different in vitro selectivities for the presynaptic alpha-receptor, on mean arterial pressure and serum renin activity were determined in the conscious rat. Both drugs resulted in dose-related reductions in mean arterial pressure and dose-related increase in heart rate and serum renin activity. However, consistent with the greater selectivity of prazosin for the postsynaptic alpha-receptor, a given reduction in arterial pressure was associated with a lesser increment in heart rate and serum renin activity after prazosin than after the nonselective agent phentolamine. The differential effects of these agents on heart rate and serum renin activity are consistent with different degrees of blockade of a functionally significant presynaptic alpha-receptor.
Authors:
R M Graham; W A Pettinger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  1     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1979 Sep-Oct
Date Detail:
Created Date:  1980-06-25     Completed Date:  1980-06-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  497-502     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Heart Rate / drug effects*
Male
Phentolamine / pharmacology*
Prazosin / pharmacology*
Quinazolines / pharmacology*
Rats
Receptors, Adrenergic / drug effects*
Receptors, Adrenergic, alpha / drug effects*
Renin / blood*
Chemical
Reg. No./Substance:
0/Quinazolines; 0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 19216-56-9/Prazosin; 50-60-2/Phentolamine; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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