Document Detail


Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.
MedLine Citation:
PMID:  19390239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent studies have suggested that allergic rhinitis is closely related to bronchial asthma, reflecting the "one airway-one disease" hypothesis. It is unclear if the effects of pranlukast, a leukotriene-receptor antagonist, are consistent with this hypothesis. OBJECTIVE: The goal of the study was to determine if pranlukast has effects on the upper and lower airways through a comparison of the effects of fexofenadine and pranlukast on airway hyperresponsiveness in non-asthmatic patients with cedar pollinosis before the Japanese cedar pollen season and during the peak pollen season. METHODS: Patients received fexofenadine hydrochloride plus oral mequitazine (fexofenadine group) or pranlukast hydrate plus oral mequitazine (pranlukast group) as an initial treatment. Subsequent changes in airway responsiveness to acetylcholine were measured. RESULTS: Among patients in whom coughing developed during the peak pollen season, airway responsiveness significantly increased in the fexofenadine group. In the pranlukast group, airway responsiveness did not increase significantly, regardless of the presence or absence of coughing. CONCLUSIONS: The results indicate that pranlukast hydrate inhibits airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. In turn, this suggests that cysteinyl leukotrienes have a role in increased airway responsiveness.
Authors:
Hironori Sagara; Tatsuo Yukawa; Ryuichi Kashima; Takenori Okada; Takeshi Fukuda
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2009-04-25
Journal Detail:
Title:  Allergology international : official journal of the Japanese Society of Allergology     Volume:  58     ISSN:  1440-1592     ISO Abbreviation:  Allergol Int     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-22     Completed Date:  2009-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616296     Medline TA:  Allergol Int     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  277-87     Citation Subset:  IM    
Affiliation:
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Tochigi, Japan. h-sagara@dokkyomed.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Activities of Daily Living
Adult
Anti-Allergic Agents / administration & dosage,  therapeutic use
Anti-Asthmatic Agents / administration & dosage,  therapeutic use
Antigens, Plant / immunology
Asthma*
Bronchial Hyperreactivity / drug therapy*,  immunology,  physiopathology
Bronchial Provocation Tests
Bronchoconstriction / drug effects,  physiology
Chamaecyparis / immunology
Chromones / administration & dosage,  therapeutic use*
Cough / diagnosis,  prevention & control
Cryptomeria / immunology*
Eosinophils / pathology
Female
Forced Expiratory Volume / drug effects,  physiology
Humans
Immunoglobulin E / blood,  immunology
Male
Middle Aged
Nasal Mucosa / drug effects,  pathology
Phenothiazines / administration & dosage,  therapeutic use
Pollen / immunology
Rhinitis, Allergic, Seasonal / drug therapy*,  immunology,  physiopathology
Terfenadine / administration & dosage,  analogs & derivatives,  therapeutic use
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Anti-Allergic Agents; 0/Anti-Asthmatic Agents; 0/Antigens, Plant; 0/Chromones; 0/Phenothiazines; 0/pranlukast; 138452-21-8/fexofenadine; 29216-28-2/mequitazine; 37341-29-0/Immunoglobulin E; 50679-08-8/Terfenadine; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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