Document Detail


Effects of potassium apigenin and verbena extract on the wound healing process of SKH-1 mouse skin.
MedLine Citation:
PMID:  23136845     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Tissue repair is a complex process, which may be favoured or inhibited by different factors. Potassium apigenin (AP) and other flavonoids present in verbena extract (PLX®) possess powerful anti-inflammatory properties. The aim of this study was to evaluate the effects of topical treatment with AP and PLX gels on wounds inflicted on SKH-1/CRL mice. Forty-eight SKH-1 mice were used (4 groups with 12 animals each), which were subjected to wound excision with a round scalpel, 4 mm in diameter, on the dorsal skin. Animals were divided into four groups: Group I received topical applications of apigenin gel; Group II received PLX gel; Group III received vehicle gel; Group IV acted as control. Wound contraction, re-epithelialisation, inflammation and neovascularisation (by means of immunohistochemical staining with anti-laminin) were recorded at study periods established at 2, 7 and 14 days. Re-epithelialisation was faster in Groups I and II at 7 days (56·25% grade 3 and 43·75% grade 4) compared with the other groups. The degree of inflammation showed improvement with a tendency towards statistical significance in Groups I and II at 2 and 7 days. Anti-laminin staining was more intense in the group treated with PLX at the 2- and 7-day periods. Topical treatment with PLX gel improved the degree of re-epithelialisation and inflammation and favoured neo-vascularisation of the wounds at 2 and 7 days following surgery.
Authors:
Pia Lopez-Jornet; Fabio Camacho-Alonso; Francisco Gómez-Garcia; Francisco Molina Miñano; Xabier Cañas; Ana Serafín; Julian Castillo; Vicente Vicente-Ortega
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  International wound journal     Volume:  -     ISSN:  1742-481X     ISO Abbreviation:  Int Wound J     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230907     Medline TA:  Int Wound J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. International Wound Journal © 2012 Blackwell Publishing Ltd and Medicalhelplines.com Inc.
Affiliation:
P Lopez-Jornet, MD, Oral Medicine Unit, Faculty of Medicine and Dentistry, University of Murcia, Spain F Camacho-Alonso, DDS, Oral Medicine Unit, Faculty of Medicine and Dentistry, University of Murcia, Spain F Gómez-Garcia, DDS, Department of Pathology and Anatomical Sciences, Faculty of Medicine and Dentistry, University of Murcia, Spain F Molina Miñano, DDS, Oral Medicine Unit, Faculty of Medicine and Dentistry, University of Murcia, Spain X Cañas, PhD, Laboratory Animal Applied Research Platform, Barcelona Science Park, Barcelona, Spain A Serafín, PhD, Laboratory Animal Applied Research Platform, Barcelona Science Park, Barcelona, Spain J Castillo, PhD, Department of Pathology and Anatomical Sciences, Faculty of Medicine and Dentistry, University of Murcia, Spain V Vicente-Ortega, MD, PhD, Department of Pathology and Anatomical Sciences, Faculty of Medicine and Dentistry, University of Murcia, Spain.
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