Document Detail


Effects of postnatal smoke exposure on laryngeal chemoreflexes in newborn lambs.
MedLine Citation:
PMID:  20864563     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Laryngeal chemoreflexes (LCR), which are elicited by the contact of liquids such as gastric refluxate with laryngeal mucosa, may trigger some cases of sudden infant death syndrome. Indeed, while LCR in mature mammals consist of protective responses, previous animal data have shown that LCR in immature newborns can include laryngospasm, apnea, bradycardia, and desaturation. The present study was aimed at testing the hypothesis that postnatal exposure to cigarette smoke is responsible for enhancing cardiorespiratory inhibition observed with LCR. Eight lambs were exposed to cigarette smoke (20 cigarettes/day) over 16 days and compared with seven control lambs. Urinary cotinine/creatinine ratio was measured at a level relevant to previously published levels in infants. On days 15 and 16, 0.5 ml of HCl (pH 2), milk, distilled water, or saline was injected onto the larynx via a chronic supraglottal catheter during sleep. Results showed that exposure to cigarette smoke enhanced respiratory inhibition (P < 0.05) and tended to enhance cardiac inhibition and decrease swallowing and arousal during LCR (P < 0.1). Overall, these results were observed independently of the state of alertness and the experimental solution tested. In conclusion, 16-day postnatal exposure to cigarette smoke increases cardiorespiratory inhibition and decreases protective mechanisms during LCR in nonsedated full-term lambs.
Authors:
Marie St-Hilaire; Charles Duvareille; Olivier Avoine; Anne-Marie Carreau; Nathalie Samson; Philippe Micheau; Alexandre Doueik; Jean-Paul Praud
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-09-23
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  109     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-03-25     Revised Date:  2013-10-22    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1820-6     Citation Subset:  IM    
Affiliation:
Neonatal Respiratory Research Unit, Department of Pediatrics, Université de Sherbrooke, Sherbrooke, QC, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Apnea / etiology,  physiopathology
Arousal
Biological Markers / urine
Blood Pressure
Body Temperature
Bradycardia / etiology,  physiopathology
Chemoreceptor Cells / drug effects*,  metabolism
Cotinine / urine
Cough / etiology,  physiopathology
Creatinine / urine
Deglutition
Heart Rate
Humans
Infant, Newborn
Laryngeal Nerves / drug effects*,  metabolism,  physiopathology
Reflex / drug effects*
Respiratory Rate
Sheep
Smoke / adverse effects*
Sudden Infant Death / etiology*
Time Factors
Tobacco Smoke Pollution / adverse effects*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Smoke; 0/Tobacco Smoke Pollution; 486-56-6/Cotinine; 60-27-5/Creatinine
Comments/Corrections

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