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Effects of post-resuscitation administration with sodium hydrosulfide on cardiac recovery in hypoxia-reoxygenated newborn piglets.
MedLine Citation:
PMID:  24056121     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hydrogen sulfide may protect multiple organ systems against ischemic-reperfusion injuries. It is unknown if treatment with sodium hydrosulfide (NaHS, a hydrogen sulfide donor) will improve myocardial function and minimize oxidative stress in hypoxic-reoxygenated newborn piglets. Mixed breed piglets (1-5 day, 1.5-2.5kg) were anesthetized and acutely instrumented for the measurement of systemic, pulmonary and regional (carotid, superior mesenteric and renal) hemodynamics and blood gas parameters. The piglets were induced with normocapnic alveolar hypoxia (10-15% oxygen, 2h) followed by reoxygenation with 100% (1h) then 21% oxygen (3h). At 10min of reoxygenation, either NaHS (10mg/kg, 5ml) or saline (5ml) was administered intravenously for 30min (5min bolus followed by 25min of continuous infusion) in a blinded, block-randomized fashion (n=7/group). Plasma lactate and troponin I levels and tissue markers of myocardial oxidative stress were also determined. Two hours hypoxia caused cardiogenic shock (45±3% of respective normoxic baseline), reduced regional perfusion with metabolic acidosis (pH 6.94±0.02). NaHS infusion significantly improved recovery of cardiac index (84±3% vs. 72±5% in controls), systemic oxygen delivery (84±3% vs. 72±5% in controls) and systemic oxygen consumption (102±5% vs. 84±6% in controls) at 4h of reoxygenation. NaHS had no significant effect on systemic and pulmonary blood pressures, regional blood flows, plasma lactate and troponin I levels. The myocardial glutathionine ratio was reduced in piglets treated with NaHS (vs. controls, P<0.05). Post-resuscitation administration of NaHS improves cardiac function and systemic perfusion and attenuates myocardial oxidative stress in newborn piglets following hypoxia-reoxygenation.
Authors:
Po-Yin Cheung; Margaret Miedzyblocki; Tze-Fun Lee; David L Bigam
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-18
Journal Detail:
Title:  European journal of pharmacology     Volume:  -     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Elsevier B.V. All rights reserved.
Affiliation:
Departments of Surgery University of Alberta, Edmonton, Alberta, Canada; Departments of Surgery Pediatrics, University of Alberta, Edmonton, Alberta, Canada. Electronic address: poyin@ualberta.ca.
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