Document Detail

Effects of post-exercise supplements on glycogen repletion in skeletal muscle.
MedLine Citation:
PMID:  12447829     Owner:  NLM     Status:  MEDLINE    
Post-exercise carbohydrate supplementation has been routinely used to enhance glycogen concentrations in skeletal muscle, particularly during multiple-day athletic events. Consumption of protein hydrolysates mixed with carbohydrate supplements during the post-exercise period may increase insulin response and cause glycogen repletion in skeletal muscle. A group of Alaskan sled dogs were selected to examine post-exercise supplementation in a paired crossover study design. The dogs were subjected to the same exercise regimen and provided one of three treatments-water, glucose polymers, or glucose polymers with protein hydrolysates-over a 2-month period. Parameters tested at various post-exercise time points included plasma insulin, glucagon and glucose concentrations, and skeletal muscle glycogen content to gain a better understanding of glucose metabolism and glycogen repletion. The results showed an enhanced insulin, glucose, and glucagon response immediately after supplementation and significantly increased glycogen concentrations in skeletal muscle within 24 hours when dogs received either of the glucose-containing supplements compared with water alone. There were no differences in the plasma parameters or skeletal muscle glycogen stores in dogs provided the glucose polymers alone or the glucose polymers plus protein hydrolysates. Thus, post-exercise carbohydrate supplementation increased muscle glycogen repletion, but inclusion of protein hydrolysates in the supplements provided no additional benefits.
Joseph J Wakshlag; Kimberly A Snedden; Annette M Otis; Christopher A Kennedy; Todd P Kennett; Janet M Scarlett; Francis A Kallfelz; Gary M Davenport; Arleigh J Reynolds; Gregory A Reinhart
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary therapeutics : research in applied veterinary medicine     Volume:  3     ISSN:  1528-3593     ISO Abbreviation:  Vet. Ther.     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-26     Completed Date:  2003-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100936368     Medline TA:  Vet Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  226-34     Citation Subset:  IM    
Cornell University, College of Veterinary Medicine, Department of Clinical Sciences, Ithaca, NY 14853, USA.
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MeSH Terms
Blood Glucose / drug effects
Dietary Carbohydrates / administration & dosage,  pharmacology*
Dietary Proteins / administration & dosage,  pharmacology*
Dietary Supplements
Drug Administration Schedule
Glucagon / blood
Glucose / administration & dosage,  pharmacology
Glycogen / analysis,  metabolism*
Insulin / blood
Motor Activity / physiology*
Muscle, Skeletal / drug effects*,  metabolism*
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Proteins; 11061-68-0/Insulin; 50-99-7/Glucose; 9005-79-2/Glycogen; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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