Document Detail

Effects of positive end-expiratory pressure on tissue gas tensions and oxygen transport.
MedLine Citation:
PMID:  6430647     Owner:  NLM     Status:  MEDLINE    
To determine whether positive end-expiratory pressure (PEEP) impairs peripheral tissue oxygenation, hemodynamic variables including blood and subcutaneous tissue gas tensions were measured at 0, 5, 10, 15, and 20 cm H2O of PEEP, in 9 patients who were being mechanically ventilated for acute pulmonary failure. Increasing the level of PEEP produced parallel decreases in cardiac output and oxygen delivery (DO2 = cardiac output X arterial oxygen content); however, there were no significant changes in mean arterial blood pressure (MAP), oxygen consumption (VO2), mixed-venous oxygen tension (PvO2), pH, or base excess. Subcutaneous tissue oxygen (PtO2) and carbon dioxide (PtCO2) tensions, which were directly measured in the femoral region by a mass spectrometer, also remained at their baseline levels (zero end-expiratory pressure). We concluded that peripheral tissue oxygenation is not impaired up to the level of 20 cm H2O of PEEP, even though DO2 significantly decreases.
H Sugimoto; N Ohashi; Y Sawada; T Yoshioka; T Sugimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  12     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-09-04     Completed Date:  1984-09-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  661-3     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Carbon Dioxide / blood
Cardiac Output
Mass Spectrometry
Middle Aged
Oxygen / blood*
Oxygen Consumption*
Positive-Pressure Respiration*
Respiratory Insufficiency / blood,  metabolism,  therapy*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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