Document Detail

Effects of positive end-expiratory pressure on oscillated volume during high frequency chest compression in children with cystic fibrosis.
MedLine Citation:
PMID:  12687028     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effects of positive end-expiratory pressure (PEEP) on end-expiratory lung volume (EELV) and mean oscillated volume (V(osc)) during high frequency chest compression (HFCC). DESIGN: A clinic-based prospective intervention study. SETTING: Pulmonary function laboratory, University of Alberta, Edmonton, Alberta. POPULATION: Nine children with cystic fibrosis with little or no obstructive airway disease who were selected from the outpatient Cystic Fibrosis and Pediatric Pulmonary Clinics at the University of Alberta Hospital, Edmonton, Alberta. METHODS: Each child received HFCC alone (at 10 Hz with chest wall pressure of 8 cm H2O) and HFCC plus PEEP. A closed circuit spirometry system was used to measure HFCC- and PEEP-induced changes in EELV, expressed as per cent baseline functional residual capacity (FRC) measured using helium dilution. An isothermic chamber permitted measurement of V(osc). RESULTS: HFCC caused a significant 9% decrease in EELV. Adding 2.0 +/- 0.3 cm H2O of PEEP increased EELV back to at least the FRC level. With HFCC alone, Vosc was significantly lower during spontaneous expiration than during spontaneous inspiration, but adding PEEP to HFCC increased V(osc), especially during spontaneous expiration. CONCLUSIONS: Adding PEEP during HFCC prevents the decrease in EELV and increases V(osc). Therefore, PEEP may improve HFCC-induced mucus clearance in children with cystic fibrosis.
Cara F Dosman; Peter C Zuberbuhler; Joan I Tabak; Richard L Jones
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian respiratory journal : journal of the Canadian Thoracic Society     Volume:  10     ISSN:  1198-2241     ISO Abbreviation:  Can. Respir. J.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-10     Completed Date:  2003-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9433332     Medline TA:  Can Respir J     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  94-8     Citation Subset:  IM    
Department of Pediatrics, University of Alberta, Edmonton, Canada.
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MeSH Terms
Chest Wall Oscillation
Cystic Fibrosis / diagnosis,  therapy*
Expiratory Reserve Volume*
Intervention Studies
Positive-Pressure Respiration / methods*
Prospective Studies
Pulmonary Gas Exchange
Respiratory Function Tests
Severity of Illness Index
Total Lung Capacity
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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