Document Detail


Effects of positive end-expiratory pressure and body position on pulmonary blood flow redistribution in mechanically ventilated normal pigs.
MedLine Citation:
PMID:  12226046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY OBJECTIVES: To assess the respective effects of position and positive end-expiratory pressure (PEEP) on the distribution of regional pulmonary blood flow (PBF). DESIGN: Prospective randomized animal study. SETTING: Animal research facility in a university hospital. PARTICIPANTS: Normal pigs that were tracheostomized, anesthetized, and mechanically ventilated. INTERVENTIONS: PBF was measured in seven pigs in the supine position (SP) and the prone position (PP) at both zero end-expiratory pressure (ZEEP) and 10 cm H(2)O of PEEP. The regional PBF was assessed by the radioactive microsphere method. The lungs from each pig were sliced into 90 samples. The heterogeneity of PBF was estimated from its coefficient of variation. MEASUREMENTS AND RESULTS: The lung samples had a mean (+/- SD) weight of 1.60 +/- 0.39 g. Changing position from SP to PP at ZEEP redistributed PBF toward the anterior, superior, and peripheral regions and did not significantly reduce the coefficient of variation for regional PBF (reduction, 44.7 +/- 7% to 42.2 +/- 8%). Changing from the SP to PP position at PEEP induced a similar, but more marked, redistribution of PBF and a significant reduction in the coefficient of variation from 53 +/- 13% to 30.4 +/- 7% (p < 0.001). In the SP, PEEP redistributed PBF toward the posterior, inferior, and central regions without changing the heterogeneity of PBF. In the PP, PEEP had little effect on the PBF redistribution but significantly reduced the coefficient of variation of PBF from 42.2 +/- 8% to 30.4 +/- 7% (p < 0.05). CONCLUSIONS: Pigs in the PP had altered gravitational dependence of PBF compared to that observed when pigs were in the SP. This effect was enhanced by using a PEEP of 10 cm H(2)O.
Authors:
Jean-Christophe Richard; Francois Decailliot; Marc Janier; Guy Annat; Claude Guérin
Related Documents :
16941166 - Does peep impair the hepatic outflow in patients following liver transplantation?
17006066 - Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure pr...
10634056 - Contrast echocardiography and transcranial doppler sonography for detection of a patent...
19996966 - Positive end-expiratory pressure.
6824376 - Therapeutic benefits of 5-hydroxytryptamine inhibition following pulmonary embolism.
12871966 - Sigmoidal equation for lung and chest wall volume-pressure curves in acute respiratory ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  122     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-12     Completed Date:  2002-10-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  998-1005     Citation Subset:  AIM; IM; S    
Affiliation:
Centre Etude et de Recherches en Tomographie par Emission de Positrons, Hôpital Neuro-Cardiologique, Lyon, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Female
Gravitation
Lung / blood supply*
Male
Positive-Pressure Respiration*
Posture / physiology*
Regional Blood Flow / physiology
Swine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lack of agreement between thermodilution and fick cardiac output in critically ill patients.
Next Document:  Evolution of the stone heart after prolonged cardiac arrest.