Document Detail

Effects of positive end-expiratory pressure on intracranial pressure and cerebral perfusion pressure.
MedLine Citation:
PMID:  12168368     Owner:  NLM     Status:  MEDLINE    
The effect of positive end-expiratory pressure (PEEP) on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) has been reported by several investigators, without any consensus being reached. Acute neurological and neurosurgical patients suffer intracranial hypertension and acute lung injury with hypoxemia. Since PEEP may improve hypoxemia but elevate ICP and decrease CPP, it is important to determine the influence of varying levels of PEEP on ICP and CPP. The aim of the study was to investigate the changes in ICP and CPP associated with different levels of PEEP. Twenty patients requiring ICP monitoring and mechanical ventilation were enrolled. Patients had severe head injury (n = 10), spontaneous intracerebral haemorrhage (n = 5), and subarachnoid haemorrhage (n = 5). PEEP was raised from 5 (basal) to 15 cm H2O in steps of 5 cm H2O. After at least 10 minutes of each new PEEP setting, ICP and CPP were measured. PEEP at 10 and 15 cm H2O produced a significant (p < 0.05) increase in intracranial pressure 11.6 +/- 5.6 and 14.6 +/- 6.28 mm Hg, respectively; no significant (p = 0.819) change occurred in CPP.
W Videtta; F Villarejo; M Cohen; G Domeniconi; R Santa Cruz; O Pinillos; F Rios; B Maskin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  81     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2002  
Date Detail:
Created Date:  2002-08-09     Completed Date:  2003-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  93-7     Citation Subset:  IM    
ICU, Hospital Nacional Prof. A. Posadas, University of Buenos Aires, Haedo, Argentina.
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MeSH Terms
Carbon Dioxide / blood
Cerebral Hemorrhage / surgery,  therapy
Cerebrovascular Circulation / physiology*
Craniocerebral Trauma / surgery,  therapy*
Intracranial Hypertension / therapy
Intracranial Pressure / physiology*
Monitoring, Intraoperative / methods
Oxygen / blood
Positive-Pressure Respiration*
Subarachnoid Hemorrhage / surgery,  therapy
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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