Document Detail


Effects of porcine growth hormone on glucose metabolism of pigs: II. Glucose tolerance, peripheral tissue insulin sensitivity and glucose kinetics.
MedLine Citation:
PMID:  2656619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was conducted to determine whether the increase in serum glucose observed in pigs treated chronically with pGH is due to an increase in hepatic glucose output or to an impairment in glucose clearance. Barrows (n = 4 per treatment) were treated with pituitary derived pGH (ppGH), recombinant pGH analog (rpGH) or vehicle. Pigs were treated for 28 d by daily i.m. injections. Insulin tolerance and glucose tolerance tests (GTT) were performed on d 19 and 21, respectively, following treatment with pGH. Glucose turnover was quantified on d 28 using [6-3H]glucose. Chronically treating pigs with pGH resulted in a significant decrease (26%; P less than .05) in glucose clearance, as determined by the GTT. Glucose clearance was affected similarly by ppGH and rpGH. Intra-arterial glucose infusion markedly increased plasma insulin concentration in pGH-treated pigs. Peak plasma insulin response was 87% and 58%, respectively, higher (P less than .05) in ppGH- and rpGH-treated than in control pigs. Insulin infusion elicited a marked hypoglycemia in pigs; however, the extent and duration of hypoglycemia were significantly less in pGH-treated pigs (ppGH or rpGH). Glucose production rates were 23% higher (P = .085) in ppGH-treated than in control pigs. These results establish that the hyperglycemia induced by pGH is the result of an increase in hepatic glucose output and a concurrent impairment in glucose clearance.
Authors:
R Gopinath; T D Etherton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of animal science     Volume:  67     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-06-30     Completed Date:  1989-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  689-97     Citation Subset:  IM    
Affiliation:
Dept. of Diary and Anim. Sci., Pennsylvania State University, University Park 16802.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism*
Catheterization, Peripheral / veterinary
Catheters, Indwelling
Glucose / administration & dosage,  pharmacokinetics*
Glucose Tolerance Test / veterinary
Growth Hormone / administration & dosage,  pharmacology*
Infusions, Intra-Arterial / veterinary
Injections, Intramuscular / veterinary
Insulin / administration & dosage,  blood,  metabolism*
Liver / metabolism
Male
Random Allocation
Swine / blood,  metabolism*
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 50-99-7/Glucose; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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