Document Detail

Effects of polyvalent cations and dihydropyridine calcium channel blockers on recovery of CNS white matter from anoxia.
MedLine Citation:
PMID:  2234507     Owner:  NLM     Status:  MEDLINE    
The effects of anoxic injury on the functional integrity of mammalian central white matter were studied electrophysiologically using the rat optic nerve model. Previous studies on this model have shown that extracellular Ca2+ is critical to the production of irreversible anoxic injury, and suggest that during anoxia Ca2+ crosses the membrane to enter the intracellular compartment. We attempted to elucidate the mechanism by which this damaging Ca2+ influx occurs. The inorganic Ca2+ channel blockers Mn2+ (1 mM), Co2+ (1 mM) or La3+ (0.1 mM) had no effect on recovery of the area under the compound action potential after a standard 60 min period of anoxia; only Mg2+ (10 mM) significantly improved recovery (54.9 +/- 8.9% vs. 28.7 +/- 10.1%, P less than 0.005). Treatment with organic Ca2+ channel blockers of the dihydropyridine class, nifedipine (1-10 microM) or nimodipine (1-40 microM), also had no effect on recovery from anoxia. We conclude that Ca2+ influx during anoxia does not occur via conventional Ca2+ channels sensitive to polyvalent cations or dihydropyridines.
P K Stys; B R Ransom; S G Waxman
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  115     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-12-12     Completed Date:  1990-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  293-9     Citation Subset:  IM    
Department of Neurology, Yale University School of Medicine, New Haven, CT 06510.
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MeSH Terms
Action Potentials / drug effects
Calcium / physiology*
Calcium Channel Blockers / pharmacology*
Hypoxia, Brain / metabolism*,  physiopathology
Nifedipine / pharmacology*
Nimodipine / pharmacology*
Optic Nerve / metabolism*,  physiopathology
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 66085-59-4/Nimodipine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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