| Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice. | |
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MedLine Citation:
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PMID: 22390908 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of the present study was to assess whether the administration of polyunsaturated fatty acids (PUFAs) would lead to alterations in cocaine-conditioned place preference by correlating behavioral data and plasma levels of PUFAs. METHODS: Five groups of C57Bl/6J mice received a linseed oil supplement or a control solution for 19 days and were conditioned to cocaine. RESULTS: PUFAs did not exert a protective effect against cocaine-conditioned place-preference behavior, although there were significant differences in the levels of eicosapentaenoic acid (EPA) and linoleic acid among the groups tested. Higher doses of PUFAs might be necessary to induce a change in the plasma level of EPA in cocaine-conditioned mice. DISCUSSION: PUFAs had no effect on cocaine-conditioned place preference. |
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Authors:
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Eserian Jaqueline Kalleian; D'Almeida Vânia; Andersen Monica Levy; Galduróz José Carlos Fernandes |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-16 |
Journal Detail:
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Title: Nutritional neuroscience Volume: - ISSN: 1476-8305 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-3-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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