| Effects of polyunsaturated fatty acids on cardiac voltage-activated K(+) currents in adult ferret cardiomyocytes . | |
| | |
MedLine Citation:
|
PMID: 12195273 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
This study was carried out in adult ferret cardiomyocytes to investigate the effects of the n-3 polyunsaturated fatty acids (PUFAs) on voltage-gated K(+) currents. We report that the two outward K(+) currents: the transient outward K(+) current (I(to)) and the delayed rectifier K(+) current (I(K)), are both inhibited by the n-3 PUFAs, while the inwardly rectifying K(+) current (I(K1)) is unaffected by the n-3 PUFAs. Docosahexaenoic acid (C22:6n-3, DHA) produced a concentration dependent suppression of I(to) and I(K) in adult ferret cardiomyocytes with an IC(50) of 7.5 and 20 micromol/L, respectively; but not I(K1). In addition, eicosapentaenoic acid (C20:5n-3, EPA) had the effects on the three K(+) channels similar to DHA. Arachidonic acid (C20:4n-6, AA) at 5 or 10 micromol/L, after an initial inhibitory effect on I(K), caused an activation of I(K),AA which was prevented by pretreatment with indomethacin, a cyclooxygenase inhibitor. Monounsaturated and saturated fatty acids, which are not antiarrhythmic, lack the effects on these K(+) currents. Our results demonstrate that the n-3 PUFAs inhibit cardiac I(to) and I(K) with much less potency compared to their effects on cardiac Na(+) and Ca(2+) currents as we reported previously. This inhibition of the cardiac ion currents by the n-3 PUFAs may contribute to their antiarrhythmic actions. |
| | |
Authors:
|
Yong-Fu Xiao; James P Morgan; Alexander Leaf |
Related Documents
:
|
16413743 - Gestational exposure to methylmercury and n-3 fatty acids: effects on high- and low-rat... 19590823 - Polyunsaturated fatty acids and cardiovascular disease. 3972913 - Utilization and formation of amino acids by chicken epiphyseal chondrocytes: comparativ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Sheng li xue bao : [Acta physiologica Sinica] Volume: 54 ISSN: 0371-0874 ISO Abbreviation: Sheng Li Xue Bao Publication Date: 2002 Aug |
Date Detail:
|
Created Date: 2002-08-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 20730130R Medline TA: Sheng Li Xue Bao Country: China |
Other Details:
|
Languages: eng Pagination: 271-81 Citation Subset: IM |
Affiliation:
|
Stem Cell Research Laboratory, Beth Israel Deaconess Medical Center; Massachusetts General Hospital; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. yxiao@caregroup.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
DA12762/DA/NIDA NIH HHS; DK38165/DK/NIDDK NIH HHS; HL62284/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thunderstorm-associated asthma or shortness of breath epidemic: a Canadian case report.
Next Document: [The sinus node itself also plays a role in heart rate slowing down during postnatal development].