Document Detail


Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.
MedLine Citation:
PMID:  22743086     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.
Authors:
Rossella Fioravanti; Ignacio Celestino; Roberta Costi; Giuliana Cuzzucoli Crucitti; Luca Pescatori; Leonardo Mattiello; Ettore Novellino; Paola Checconi; Anna Teresa Palamara; Lucia Nencioni; Roberto Di Santo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-4
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  -     ISSN:  1464-3391     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Istituto Pasteur Cenci Bolognetti - Dip. Chimica e Tecnologie del Farmaco, "Sapienza" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
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