| Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action. | |
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MedLine Citation:
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PMID: 22743086 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein. |
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Authors:
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Rossella Fioravanti; Ignacio Celestino; Roberta Costi; Giuliana Cuzzucoli Crucitti; Luca Pescatori; Leonardo Mattiello; Ettore Novellino; Paola Checconi; Anna Teresa Palamara; Lucia Nencioni; Roberto Di Santo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-4 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: - ISSN: 1464-3391 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Istituto Pasteur Cenci Bolognetti - Dip. Chimica e Tecnologie del Farmaco, "Sapienza" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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