| Effects of polymyxin B immobilized fiber on urinary N-acetyl-beta-glucosaminidase in patients with severe sepsis. | |
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MedLine Citation:
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PMID: 15672789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Severe sepsis is known to cause multiple organ failure, including renal dysfunction. During sepsis, endotoxin targets the renal proximal tubular cells, the function of which can be evaluated on the basis of urinary N-acetyl-beta-glucosaminidase (NAG). We investigated whether urinary NAG activity is altered in patients with severe sepsis and whether treatment with polymyxin B immobilized fibers (PMX-F) affects this activity. Subjects of this study were 120 patients with severe sepsis and 60 healthy volunteers matched for age and gender. Patients were randomly assigned to one of two treatments: PMX-F treatment (n = 70) or conventional treatment (n = 50). The plasma endotoxin level was significantly reduced, from 34.6 +/- 10.2 to 6.8 +/- 2.4 pg/ml (p < 0.01) in patients treated with PMX-F, and the urinary NAG/creatinine ratio was reduced from 46.5 +/- 26.8 U/gm to 18.6 +/- 13.6 U/gm (p < 0.01). The plasma endotoxin level and urinary NAG/creatinine ratio were unchanged in patients who received conventional treatment. The increased urinary NAG/creatinine ratio in patients with severe sepsis may reflect proximal tubular dysfunction. PMX-F is effective in reducing proximal tubular dysfunction, in part owing to reduced plasma endotoxin levels. |
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Authors:
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Tsukasa Nakamura; Yasuhiro Kawagoe; Takaharu Matsuda; Yoshihiko Ueda; Hikaru Koide |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 50 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 2004 Nov-Dec |
Date Detail:
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Created Date: 2005-01-27 Completed Date: 2005-06-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 563-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylglucosaminidase
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urine* Aged Creatinine / urine Endotoxins / blood Female Humans Male Middle Aged Polymyxin B / therapeutic use* Regression Analysis Sepsis / blood, drug therapy*, physiopathology*, urine Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 1404-26-8/Polymyxin B; 60-27-5/Creatinine; EC 3.2.1.52/Acetylglucosaminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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