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Effects of polydisperse crowders on aggregation reactions: A molecular thermodynamic analysis.
MedLine Citation:
PMID:  21322718     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Intracellular crowding in biological systems is usually mimicked in in vitro experiments by adding single crowders at high volume fractions, without taking into consideration the polydispersity of the crowders in the cellular environment. Here, we develop a molecular thermodynamic formalism to examine the effects of size-polydispersity of crowders on aggregation reaction equilibria. Although the predominantly common practice so far has been to appeal to the entropic (excluded-volume) effects in describing crowding effects, we show that the internal energy (hence, the enthalpy) of the system could dramatically alter the effects, even qualitatively, particularly in the case of a mixture of crowders, depending on the changes in the covolume of the products relative to that of the reactants and on the preferential binding or exclusion of the crowders by the reactants and products. We also show that in the case of polydisperse crowders the crowders with the largest size difference dominate the overall changes in the yield of the reaction, depending on the individual concentrations of the crowders.
Authors:
Dhawal Shah; Aik Lee Tan; Vigneshwar Ramakrishnan; Jianwen Jiang; Raj Rajagopalan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of chemical physics     Volume:  134     ISSN:  1089-7690     ISO Abbreviation:  J Chem Phys     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375360     Medline TA:  J Chem Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  064704     Citation Subset:  IM    
Affiliation:
Chemical & Pharmaceutical Engineering Program, The Singapore-MIT Alliance, National University of Singapore, Singapore 117576, SingaporeDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576, Singapore.
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