| Effects of polydatin on attenuating ventricular remodeling in isoproterenol-induced mouse and pressure-overload rat models. | |
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MedLine Citation:
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PMID: 20603198 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The study was designed to examine the effects of polydatin on ventricular remodeling induced by isoproterenol in mice and by abdominal aortic banding in rats. Polydatin reduced cardiac weight indexes in mice and rats, lowered the contents of cyclic AMP and angiotensin II in mice. It also decreased the size of cardiomyocyte, the levels of aldosterone, tumor necrosis factor-α, angiotensin II and endothelin-1, reduced ventricular collagen volume and decreased blood pressure in rats. The results demonstrate that polydatin has the beneficial effects on attenuating ventricular remodeling, which are associated with its inhibiting the activation of neurohormone, especially in rennin-angiotensin-aldosterone system. |
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Authors:
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Jian Ping Gao; Chang Xun Chen; Wei Liang Gu; Qi Wu; Ying Wang; Jian Lü |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-18 |
Journal Detail:
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Title: Fitoterapia Volume: 81 ISSN: 1873-6971 ISO Abbreviation: Fitoterapia Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: Netherlands |
Other Details:
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Languages: eng Pagination: 953-60 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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