Document Detail


Effects of pleural pressure and abdominal pressure on diaphragmatic blood flow.
MedLine Citation:
PMID:  3980376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this experiment was to determine if blood flow to the diaphragm is affected by generating the transdiaphragmatic pressure mainly with positive abdominal pressure or mainly with negative pleural pressure, during both sustained and intermittent diaphragmatic contractions. Diaphragmatic blood flow was measured in anesthetized mongrel dogs by the radionuclide-labeled microsphere method. Sustained and intermittent tetanic diaphragmatic contractions were produced with 1) free abdomen and closed chest (high negative pleural pressure) and 2) bound abdomen and open chest (high positive abdominal pressure). During sustained contractions, diaphragmatic blood flow at maximum levels of activation was significantly higher with negative pleural pressure (P less than 0.05). In contrast with this, intermittent diaphragmatic contractions did not yield a significant difference between diaphragmatic blood flow with negative pleural pressure and with positive abdominal pressure at maximal levels of transdiaphragmatic pressure. During both sustained and intermittent contractions, blood pressure, as measured from the carotid artery, did not vary significantly between negative pleural pressure and positive abdominal pressure. We conclude that during sustained tetanic diaphragmatic contractions, diaphragmatic blood flow is obstructed by high positive abdominal pressures, but during intermittent diaphragmatic contractions, high positive abdominal pressures do not affect total blood flow, since any inhibition of blood flow during the contractile period can be compensated for during the relaxation period between contractions.
Authors:
B Buchler; S Magder; H Katsardis; Y Jammes; C Roussos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  58     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-05-20     Completed Date:  1985-05-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  691-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abdomen / physiology*
Animals
Cardiac Output
Diaphragm / blood supply*,  physiology
Dogs
Electric Stimulation
Microspheres
Muscle Contraction
Oxygen Consumption
Pleura / physiology*
Pressure
Radioisotopes / diagnostic use
Regional Blood Flow
Chemical
Reg. No./Substance:
0/Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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