Document Detail

Effects of platelet activating factor on vascular permeability of the middle ear mucosa.
MedLine Citation:
PMID:  9228864     Owner:  NLM     Status:  MEDLINE    
Platelet activating factor (PAF), a potent inflammatory mediator, seems to play a significant role in the pathogenesis of otitis media with effusion (OME), along with other inflammatory mediators such as leukotrienes and prostaglandins. The purpose of this study was to investigate the effect of PAF on the vascular permeability of middle ear mucosa, in an experimental OME model using chinchillas. We injected PAF in doses of 1, 4, 8, and 16 micrograms and normal saline as a control into the bullae of chinchillas. Vascular permeability was measured by the Evans blue vital dye technique. All the PAF-injected animals showed a significant increase in middle ear vascular permeability compared to the control group. This study demonstrated that PAF in the middle ear cavity contributes significantly to the development of OME by increasing the vascular permeability of the middle ear mucosa.
C K Rhee; Y S Park; S A Long; T T Jung; D Davamony
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  106     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-07     Completed Date:  1997-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  604-7     Citation Subset:  AIM; IM    
Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine, Cheonan, Korea.
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MeSH Terms
Capillary Permeability / drug effects*
Disease Models, Animal
Ear, Middle / blood supply*
Mucous Membrane / blood supply
Otitis Media with Effusion / immunology*
Platelet Activating Factor / immunology*
Reg. No./Substance:
0/Platelet Activating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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