| Effects of platelet-activating factor on myocardial contraction and myocardial relaxation of isolated perfused guinea pig hearts. | |
| | |
MedLine Citation:
|
PMID: 1703596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Platelet-activating factor (PAF) is an important mediator of cardiovascular shock owing to immunologic reactions, including anaphylaxis and endotoxaemia. Previous studies have shown that PAF is a potent cardio-depressive agent causing a marked coronary constriction and a sustained impairment of myocardial contractility. In this study, we attempted to characterize further the prolonged PAF effects on coronary circulation and myocardial contractile force in isolated guinea pig hearts perfused at constant pressure (60 cm H2O) or constant flow which was adjusted to a level of 100% above basal flow. In addition, the PAF-induced changes of ventricular systolic and diastolic function were distinguished. In the hearts perfused at constant pressure, PAF induced a dose-dependent (0.57, 5.7, and 57 pmol/min) decrease of coronary flow rates, left ventricular pressure (LVP), LV contraction (peak positive dP/dt) and LV relaxation (peak negative dP/dt). The decrement of peak negative dP/dt was more pronounced than that of peak positive dP/dt. Maintenance of coronary flow rates only attenuated, but did not suppress, the PAF-induced ventricular malfunction, and it improved ventricular relaxation less than it did ventricular contraction. Pretreatment with the PAF antagonist WEB 2086 (19.7 nmol/min) almost completely abolished the effects of the highest PAF dose on coronary circulation and ventricular contractile parameters. We conclude that the cardiodepressive effects of PAF are due to coronary constriction and direct contractile events. Furthermore, PAF impairs ventricular diastolic function more than ventricular systolic function. |
| | |
Authors:
|
S B Felix; G Baumann; Z Ahmad; T Hashemi; M Niemczyk; W E Berdel |
Related Documents
:
|
1711636 - Effects of intravenous endothelin on hemodynamics and cardiac contractility in consciou... 8726226 - Glucose is arrhythmogenic in the anoxic-reoxygenated embryonic chick heart. 9710796 - Phospholamban modulates murine atrial contractile parameters and responses to beta-adre... 18926146 - A randomized controlled trial to evaluate the safety and efficacy of cardiac contractil... 19889656 - Anatomy and myoarchitecture of the left ventricular wall in normal and in disease. 20381726 - The role of echocardiography in hemodynamic assessment of septic shock. |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 16 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1990 Nov |
Date Detail:
|
Created Date: 1991-03-01 Completed Date: 1991-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 750-6 Citation Subset: IM |
Affiliation:
|
Department of Medicine I, Technische Universität München, Klinikum rechts der Isar, F.R.G. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Azepines / pharmacology Calcium / metabolism Coronary Circulation / drug effects* Dose-Response Relationship, Drug Guinea Pigs Myocardial Contraction / drug effects* Perfusion Platelet Activating Factor / pharmacology* Triazoles / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Azepines; 0/Platelet Activating Factor; 0/Triazoles; 105219-56-5/WEB 2086; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hemodynamic effects of intraatrial administration of deferoxamine or deferoxamine-pentafraction conj...
Next Document: Effects of propranolol on premature action potentials in canine Purkinje and ventricular muscle.