Document Detail


Effects of plant sterol esters in skimmed milk and vegetable-fat-enriched milk on serum lipids and non-cholesterol sterols in hypercholesterolaemic subjects: a randomised, placebo-controlled, crossover study.
MedLine Citation:
PMID:  22018049     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Plant sterol (PS)-supplemented foods are recommended to help in lowering serum LDL-cholesterol (LDL-C). Few studies have examined the efficacy of PS-enriched skimmed milk (SM) or semi-SM enriched with vegetable fat (PS-VFM). There is also insufficient information on factors predictive of LDL-C responses to PS. We examined the effects of PS-SM (0·1 % dairy fat) and PS-VFM (0·1 % dairy fat plus 1·5 % vegetable fat) on serum lipids and non-cholesterol sterols in hypercholesterolaemic individuals. In a placebo-controlled, crossover study, forty-three subjects with LDL-C>1300 mg/l were randomly assigned to three 4-week treatment periods: control SM, PS-SM and PS-VFM, with 500 ml milk with or without 3·4 g PS esters (2 g free PS). Serum concentrations of lipids and non-cholesterol sterols were measured. Compared to control, LDL-C decreased by 8·0 and 7·4 % (P < 0·015, both) in the PS-SM and PS-VFM periods, respectively. Serum lathosterol:cholesterol (C) ratios increased by 11-25 %, while sitosterol:C and campesterol:C ratios increased by 70-120 % with both the PS-fortified milk. Adjusted LDL-C reductions were variably enhanced in participants with basal low serum lathosterol/C or conversely high sitosterol/C and campesterol/C. Subjects with post-treatment serum PS:C ratios above the median showed mean LDL-C changes of - 5·9 to - 10·4 %, compared with 1·7 to - 2·9 % below the median. In conclusion, consumption of 2 g/d of PS as PS-SM and PS-VFM lowered LDL-C in hypercholesterolaemic subjects to a similar extent. Basal and post-treatment changes in markers of cholesterol metabolism indicating low cholesterol synthesis and high cholesterol absorption predicted improved LDL-C responses to PS.
Authors:
Patricia Casas-Agustench; Mercè Serra; Ana Pérez-Heras; Montserrat Cofán; Xavier Pintó; Elke A Trautwein; Emilio Ros
Related Documents :
21744359 - Effect of breed on performance and meat quality of first parity sows in a seasonal orga...
1587569 - Substrate oxidation and the contribution of protein oxidation to energy expenditure aft...
22062319 - Breed effect on carcase and meat quality of suckling lambs.
6998739 - Hormonal correlates of hypophagia in white-tailed deer.
6421429 - Relation between osmolality of diet and gastrointestinal side effects in enteral nutrit...
22193039 - Effects of calf diet, antioxidants, packaging type and storage time on beef steak storage.
12589689 - Early photoperiod history and short-day responsiveness in siberian hamsters.
19270339 - Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons.
8274889 - Interactions between people's diet and their smoking habits: the dietary and nutritiona...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-10
Journal Detail:
Title:  The British journal of nutrition     Volume:  -     ISSN:  1475-2662     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-10     Citation Subset:  -    
Affiliation:
Lipid Clinic, Service of Endocrinology and Nutrition, Institut d'Investigations Biomediques August Pi Sunyer, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Early natural killer cell counts in blood predict mortality in severe sepsis.
Next Document:  Maternal undernutrition during critical windows of development results in differential and sex-speci...