Document Detail

Effects of pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) on the cardiovascular system in sheep.
MedLine Citation:
PMID:  1480509     Owner:  NLM     Status:  MEDLINE    
The cardiovascular effects of PACAP and VIP were studied in intact conscious sheep; PACAP (0.008, 0.04, 0.2, and 1.0 nmol/min) and VIP (0.07, 0.2, 0.6, and 1.8 nmol/min) were infused in conscious sheep for periods of 10 min. For each peptide there was a dose-dependent increase in heart rate. At the highest doses tested, pulse pressure and mean arterial pressure tended to increase and decrease, respectively. However, only the decrease in mean arterial pressure following the highest dose of VIP reached significance. At the highest doses tested, heart rate increased nearly threefold during the infusion while mean arterial pressure declined by 18.5%. In individual animals the decrease in blood pressure and increase in heart rate occurred simultaneously, so that we were unable to conclude whether the increase in heart rate was due to a baroreceptor reflex.
K Sawangjaroen; C R Dallemagne; R B Cross; J D Curlewis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  13     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1992 Sep-Oct
Date Detail:
Created Date:  1993-02-09     Completed Date:  1993-02-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1029-32     Citation Subset:  IM    
Department of Physiology and Pharmacology, University of Queensland, Australia.
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MeSH Terms
Blood Pressure / drug effects
Cardiovascular Physiological Phenomena
Cardiovascular System / drug effects*
Dose-Response Relationship, Drug
Heart Rate / drug effects
Neuropeptides / administration & dosage,  pharmacology*,  physiology
Pituitary Adenylate Cyclase-Activating Polypeptide
Vasoactive Intestinal Peptide / administration & dosage,  pharmacology*,  physiology
Reg. No./Substance:
0/Neuropeptides; 0/Pituitary Adenylate Cyclase-Activating Polypeptide; 37221-79-7/Vasoactive Intestinal Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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