Document Detail


Effects of pitavastatin on fasting and postprandial endothelial function and blood rheology in patients with stable coronary artery disease.
MedLine Citation:
PMID:  19531904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Because postprandial hypertriglyceridemia and hyperglycemia may promote atherosclerosis, the present study investigated the effects of a clinical dose of pitavastatin on endothelial function and blood rheology in patients with coronary artery disease (CAD) before and after eating a test meal. METHODS AND RESULTS: The 16 patients with stable CAD and mild dyslipidemia and 6 age-matched healthy men as controls were recruited. In each group, forearm blood flow (FBF) was measured during postischemic reactive hyperemia and blood samples were taken before and 2 h after the test meal. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was also measured. The patients were started on pitavastatin 2 mg/day. The tests were repeated after 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in CAD patients than in control subjects (P=0.040). Fasting and postprandial FBF during reactive hyperemia significantly improved after pitavastatin treatment (P<0.05 vs baseline data for each phase) associated with reduced urine 8-OHdG, increased plasma adiponectin and improved lipid profile. No significant differences in baseline rheological parameters were seen between controls and CAD patients. CONCLUSIONS: Pitavastatin significantly improved fasting and postprandial dyslipidemia and endothelial dysfunction in CAD patients, partly via reducing oxidative stress and increasing plasma adiponectin, although rheological parameters remained unchanged.
Authors:
Kenshiro Arao; Takanori Yasu; Tomio Umemoto; Sachimi Jinbo; Nahoko Ikeda; Shinichiro Ueda; Masanobu Kawakami; Shin-Ichi Momomura
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-16
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-24     Completed Date:  2009-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1523-30     Citation Subset:  IM    
Affiliation:
First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood
Aged
Coronary Artery Disease / blood*
Dyslipidemias / drug therapy
Endothelium, Vascular / drug effects*,  physiology
Fasting*
Hemorheology / drug effects*
Humans
Male
Middle Aged
Oxidative Stress
Postprandial Period / drug effects*
Quinolines / administration & dosage,  pharmacology*,  therapeutic use
Regional Blood Flow
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Quinolines; 147526-32-7/NK 104
Comments/Corrections
Comment In:
Circ J. 2009 Aug;73(8):1399-400   [PMID:  19628923 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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