| Effects of piperonyl butoxide on dimethylnitrosamine metabolism and toxicity in Swiss mice. | |
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MedLine Citation:
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PMID: 994247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of piperonyl butoxide (PB) on the metabolism and toxicity of dimethylnitrosamine (DMN) in Swiss mice were determined. PB, at doses of 10 and 20 mg/kg, inhibited DMN demethylase 45 min after treatment by 18 and 37%. These inhibitory effects were marked 0.5 hr after PB (640 mg/kg) treatment and reached maximal effects at 2 hr when there was 55% inhibition of enzyme activity. The inhibition by PB continued for 24 hr where enzyme activity was suppressed by 35%. At 48 hr after treatment there was stimulation of enzyme activity. Enzyme kinetic determinations showed no change in Km but Vmax decreased from 129 to 49 mumol CH2O/min-g liver. PB (640 mg/kg) inhibited DMN (500 mg/kg; im) mutagenicity in the host-mediated assay, decreasing the mutant frequency by 42%. Paradoxically, PB (640 mg/kg) had no effect on the alkylation of nucleic acids or proteins in mouse liver, kidney, lung, or spleen. In addition, pretreatment with PB (640 mg/kg) had no effect on the LD50 of DMN. |
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Authors:
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M A Friedman; V Sanders |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of toxicology and environmental health Volume: 2 ISSN: 0098-4108 ISO Abbreviation: J Toxicol Environ Health Publication Date: 1976 Sep |
Date Detail:
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Created Date: 1977-01-29 Completed Date: 1977-01-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513622 Medline TA: J Toxicol Environ Health Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 67-75 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkylation Animals Dimethylnitrosamine / metabolism, toxicity* Lethal Dose 50 Liver / enzymology Male Methyltransferases / metabolism Mice Mice, Inbred ICR Mutagens / pharmacology Nitrosamines / toxicity* Piperonyl Butoxide / pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Mutagens; 0/Nitrosamines; 51-03-6/Piperonyl Butoxide; 62-75-9/Dimethylnitrosamine; EC 2.1.1.-/Methyltransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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