| Effects of pinacidil on electrophysiological properties of epicardial border zone of healing canine infarcts: possible effects of K(ATP) channel activation. | |
| | |
MedLine Citation:
|
PMID: 12010915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: K(ATP) channels, activated by ischemia, participate in the arrhythmogenic response to acute coronary occlusion. The function of these channels in border zones of healing infarcts, where arrhythmias also arise, has not been investigated. Do these channels remain maximally activated during infarct healing, or do they downregulate after a period of time? Both might preclude further activation. METHODS AND RESULTS: Myocardial infarction was produced in dogs by ligation of the left anterior descending coronary artery. Impulse propagation in the epicardial border zone (EBZ) of 4-day-old healing infarcts was mapped during administration of pinacidil, a K(ATP) channel activator, directly into the EBZ coronary blood supply. Pinacidil restored conduction and excitability when the EBZ was initially inexcitable and had large regions of block (6 of 8 experiments). This allowed reentrant circuits to form in the EBZ, causing tachycardia (4 of 8 experiments). In hearts with an initially excitable EBZ, pinacidil shortened the effective refractory period and abolished conduction block at short cycle lengths (7 experiments). This effect prevented initiation of reentry (1 of 2 experiments). CONCLUSIONS: The response to pinacidil indicates that K(ATP) channels in the EBZ remain functional and can be activated to influence electrophysiological properties and arrhythmogenesis. |
| | |
Authors:
|
James Coromilas; Constantinos Costeas; Bernard Deruyter; Stephen M Dillon; Nicholas S Peters; Andrew L Wit |
Related Documents
:
|
6969965 - Transient right bundle branch block unmasking anteroseptal infarction concealed by left... 7376115 - Atrioventricular conduction system in univentricular heart of right ventricular type wi... 7815965 - Percutaneous radiofrequency ablation of the left bundle branch: an alternative modality... 3967405 - Wolff-parkinson-white syndrome type b and left bundle-branch block: electrophysiologic ... 11102635 - Definition of the anterior choroidal artery territory in rats using intraluminal occlud... 3184455 - Coronary aneurysms in a case of ehlers-danlos syndrome. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation Volume: 105 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2002 May |
Date Detail:
|
Created Date: 2002-05-15 Completed Date: 2002-05-24 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
|
Languages: eng Pagination: 2309-17 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pharmacology and the Center for Molecular Therapeutics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. jc47@columbia.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects Disease Models, Animal Dogs Dose-Response Relationship, Drug Electric Stimulation Electrocardiography / methods Electrodes Electrophysiologic Techniques, Cardiac Fluorescent Dyes / administration & dosage Heart / drug effects*, physiopathology* Heart Conduction System / drug effects, physiopathology Injections, Intra-Arterial Myocardial Infarction / physiopathology* Pinacidil / administration & dosage, pharmacology* Potassium Channels / drug effects*, metabolism Tachycardia, Ventricular / physiopathology Vasodilator Agents / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
HL-30557/HL/NHLBI NIH HHS; R37-HL-31393/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fluorescent Dyes; 0/Potassium Channels; 0/Vasodilator Agents; 85371-64-8/Pinacidil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cardiac membrane fatty acid composition modulates myocardial oxygen consumption and postischemic rec...
Next Document: NICE: guessing is not guidance. National Institute for Clinical Excellence.