Document Detail

Effects of pig antibacterial peptides on growth performance and intestine mucosal immune of broiler chickens.
MedLine Citation:
PMID:  19151342     Owner:  NLM     Status:  MEDLINE    
Currently, substitutions for antibiotic growth promoters in animals are attracting interest. This study investigated the effects of pig antibacterial peptides (PABP) on growth performance and small intestine mucosal immune responses in broilers. Three hundred 1-d-old Arbor Acre male broiler chickens were randomly allocated to 5 groups with 60 birds per group. The groups were control group; PABP administered in drinking water at 20 and 30 mg/L of water; or PABP supplemented in feed at 150 and 200 mg/kg of diet. The birds were fed a corn-soybean based diet for 6 wk. Chickens were weighed weekly and killed after 42 d of feeding, and growth performance was measured. Samples of the duodenum and jejunum were collected. The villus height, mucosa thickness, alkaline phosphatase activity, and numbers of secreting IgA and goblet cells were evaluated. The PABP-treated groups had greater BW and average daily gain, greater height of villus and thickness of gut mucosa, greater activity of alkaline phosphatase, higher ratio of secreting IgA, and a greater number of goblet cells compared with the control group (P<0.05). In conclusion, PABP can improve the growth performance, increase the intestinal ability to absorb nutrients, and improve the mucosal immunity of the intestine.
H Bao; R She; T Liu; Y Zhang; K S Peng; D Luo; Z Yue; Y Ding; Y Hu; W Liu; L Zhai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Poultry science     Volume:  88     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
College of Veterinary Medicine, China Agricultural University, Beijing, 100193, PR China.
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MeSH Terms
Alkaline Phosphatase / metabolism
Anti-Bacterial Agents / pharmacology
Antimicrobial Cationic Peptides* / pharmacology
Cell Count
Chickens / growth & development*,  immunology*
Goblet Cells / cytology,  drug effects
Immunoglobulin A, Secretory / metabolism
Intestinal Mucosa / drug effects*,  enzymology,  immunology*
Intestine, Small / cytology,  drug effects,  enzymology,  metabolism
Random Allocation
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antimicrobial Cationic Peptides; 0/Immunoglobulin A, Secretory; EC Phosphatase

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