Document Detail

Effects of picrotoxin and strychnine on fish retinal S-potentials: evidence for inhibitory control of depolarizing responses.
MedLine Citation:
PMID:  460729     Owner:  NLM     Status:  MEDLINE    
Simultaneous recording of the light evoked electrical signals from different classes of slow(S)-potential unit in the isolated fish retina established that picrotoxin, an antagonist of GABA, selectively suppresses the depolarizing component of C-type S-potentials. In contrast, equivalent concentrations of strychnine have no effect on S-potentials, but suppress a component of transient amacrine cell responses. On the basis of these and other experimental data [3,4] we propose a network diagram for the C-type S-potential units in the cyprinid fish retina. This network includes a GABA-ergic feed-back loop and is essentially similar to that proposed by Fuortes and Simon [5].
M B Djamgoz; K H Ruddock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  12     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-09-27     Completed Date:  1979-09-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
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MeSH Terms
Electric Stimulation
Evoked Potentials / drug effects
Picrotoxin / pharmacology*
Retina / drug effects,  physiology*
Strychnine / pharmacology*
Reg. No./Substance:
124-87-8/Picrotoxin; 57-24-9/Strychnine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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