| Effects of phytosterols in diacylglycerol as part of diet therapy on hyperlipidemia in children. | |
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MedLine Citation:
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PMID: 17215179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The incidence of hyperlipidemia in children is increasing in Japan, but drug therapy for such children is limited. The ingestion of 4% phytosterols-containing diacylglycerol (PS/DAG) decreases serum total cholesterol and low density lipoprotein cholesterol (LDL-C) concentrations in adults. In the present study, we examined the effect of PS/DAG as part of a diet therapy in pediatric patients with hyperlipidemia. METHODS: Pediatric patients with hyperlipidemia with > or =5.18mmol (200 mg/dL) serum total cholesterol and/or >or =1.70mmol (150 mg/dL) triglycerides (N=22) ingested bread containing PS/DAG (total daily intake, 10g) for 6 months. Blood chemistry was examined prior to and 2, 4, 6 months after the initiation of ingestion, and 4 months after the ingestion period. RESULTS: No significant differences in energy intake or cholesterol intake during the study period were found. After 4 months of ingestion of PS/DAG, LDL-C, lipoprotein(a) [ Lp(a)], free fatty acids and total ketone bodies decreased significantly. In seven patients with familial hypercholesterolemia, total cholesterol and remnant-like lipoprotein particles (RLP)-cholesterol also significantly decreased in addition to LDL-C and Lp(a). CONCLUSIONS: PS/DAG improves serum lipid metabolism in pediatric patients with hyperlipidemia for whom drug therapy is limited, suggesting that PS/DAG may reduce the risk of developing various diseases induced by hyperlipidemia. |
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Authors:
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Takeshi Matsuyama; Kentaro Shoji; Hideto Takase; Isamu Kamimaki; Yuriko Tanaka; Atsuko Otsuka; Hiroyuki Watanabe; Tadashi Hase; Ichiro Tokimitsu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asia Pacific journal of clinical nutrition Volume: 16 ISSN: 0964-7058 ISO Abbreviation: Asia Pac J Clin Nutr Publication Date: 2007 |
Date Detail:
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Created Date: 2007-01-11 Completed Date: 2007-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440304 Medline TA: Asia Pac J Clin Nutr Country: Australia |
Other Details:
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Languages: eng Pagination: 40-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Fussa Hospital, 1-6-1 Kamidaira, Fussa-shi, Tokyo 197-8511, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anticholesteremic Agents / administration & dosage*, adverse effects, therapeutic use Child Cholesterol / blood* Cholesterol, HDL / blood Cholesterol, LDL / blood Diglycerides / administration & dosage*, adverse effects, therapeutic use Female Humans Hyperlipidemias / diet therapy* Male Phytosterols / administration & dosage*, adverse effects, therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Diglycerides; 0/Phytosterols; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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