Document Detail


Effects of phytate on thyroid gland of rats intoxicated with cadmium.
MedLine Citation:
PMID:  23796758     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cadmium (Cd) is one of the most dangerous occupational and environmental toxins. The objective of the present study is to examine the potential prophylactic effects of phytic acid (PA) on thyroid hormones of male rats intoxicated with Cd. The male albino rats were divided into five groups: group I (control) was fed with the basal diet, group II was intoxicated with Cd in drinking water, groups III, IV, and V were intoxicated with Cd in drinking water and fed with the diet containing 3.5, 7, and 10 g of PA/kg, respectively. The results indicated that the serum calcium, iron (Fe), and total Fe binding capacity levels and serum T3 and T4 in Cd-treated rats of group II were decreased when compared with the control group, while PA-administered groups with Cd showed a significant improvement when compared with the Cd-treated rats only. Serum thyroid stimulating hormone (TSH) level was significantly increased in Cd-treated rats compared with the control group, while the addition of PA in diet decreased the high levels of TSH. These results indicated a prophylactic effect of PA against Cd-induced toxicity in rats.
Authors:
Tarek Mostafa Mohammed; Afrah F Salama; Tarek M El Nimr; Doaa M El Gamal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-24
Journal Detail:
Title:  Toxicology and industrial health     Volume:  -     ISSN:  1477-0393     ISO Abbreviation:  Toxicol Ind Health     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8602702     Medline TA:  Toxicol Ind Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University.
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