Document Detail

Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus.
MedLine Citation:
PMID:  6368289     Owner:  NLM     Status:  MEDLINE    
The effects of 12 wk of physical training in addition to hypocaloric diet (DPT group, N = 10) on body composition, carbohydrate (CHO) tolerance, and insulin secretion and action were compared with the effects of diet therapy alone (D group, N = 8) in CHO-intolerant and non-insulin-dependent diabetic subjects. Fat mass, fat-free mass (FFM), mean fasting plasma glucose, serum C-peptide, and insulin concentrations decreased similarly in both groups. The mean plasma glucose response to a mixed meal decreased approximately 20% in both treatment groups, and, after i.v. glucose, decreased 12% in the D group (P less than 0.05), but did not change in the DPT group (NS between groups). The acute serum insulin response (0-6 min) after IG increased significantly in the DPT group only (NS between groups). The mean basal endogenous glucose production (BEGP) decreased 17% (P less than 0.025) in the DPT group and by 31% (P less than 0.01) in the D group (NS between groups). Hepatic sensitivity to insulin, estimated by BEGP suppression during the euglycemic clamp, increased significantly by 25% in both groups. Total glucose disposal during the euglycemic clamp increased from 3.51 +/- 0.04 milligrams of glucose per kilogram of fat-free mass per minute (mg/kg-FFM/min) to 4.45 +/- 0.54 mg/kg-FFM/min (P less than 0.05) in the DPT group, but no change occurred in the D group (NS between groups).(ABSTRACT TRUNCATED AT 250 WORDS)
C Bogardus; E Ravussin; D C Robbins; R R Wolfe; E S Horton; E A Sims
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes     Volume:  33     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-14     Completed Date:  1984-05-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Glucose / analysis
Body Composition
C-Peptide / blood
Carbohydrate Metabolism*
Diabetes Mellitus, Type 2 / diet therapy*,  metabolism,  physiopathology,  therapy
Glucose / metabolism*
Glucose Tolerance Test
Insulin / blood
Middle Aged
Oxygen Consumption
Physical Exertion*
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin; 50-99-7/Glucose

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