| Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. | |
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MedLine Citation:
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PMID: 6368289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of 12 wk of physical training in addition to hypocaloric diet (DPT group, N = 10) on body composition, carbohydrate (CHO) tolerance, and insulin secretion and action were compared with the effects of diet therapy alone (D group, N = 8) in CHO-intolerant and non-insulin-dependent diabetic subjects. Fat mass, fat-free mass (FFM), mean fasting plasma glucose, serum C-peptide, and insulin concentrations decreased similarly in both groups. The mean plasma glucose response to a mixed meal decreased approximately 20% in both treatment groups, and, after i.v. glucose, decreased 12% in the D group (P less than 0.05), but did not change in the DPT group (NS between groups). The acute serum insulin response (0-6 min) after IG increased significantly in the DPT group only (NS between groups). The mean basal endogenous glucose production (BEGP) decreased 17% (P less than 0.025) in the DPT group and by 31% (P less than 0.01) in the D group (NS between groups). Hepatic sensitivity to insulin, estimated by BEGP suppression during the euglycemic clamp, increased significantly by 25% in both groups. Total glucose disposal during the euglycemic clamp increased from 3.51 +/- 0.04 milligrams of glucose per kilogram of fat-free mass per minute (mg/kg-FFM/min) to 4.45 +/- 0.54 mg/kg-FFM/min (P less than 0.05) in the DPT group, but no change occurred in the D group (NS between groups).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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C Bogardus; E Ravussin; D C Robbins; R R Wolfe; E S Horton; E A Sims |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Diabetes Volume: 33 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-05-14 Completed Date: 1984-05-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 311-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / analysis Body Composition C-Peptide / blood Carbohydrate Metabolism* Diabetes Mellitus, Type 2 / diet therapy*, metabolism, physiopathology, therapy Female Glucose / metabolism* Glucose Tolerance Test Humans Insulin / blood Male Middle Aged Oxygen Consumption Physical Exertion* |
| Grant Support | |
ID/Acronym/Agency:
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AM 10254/AM/NIADDK NIH HHS; AM 29866/AM/NIADDK NIH HHS; RR-109/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin; 50-99-7/Glucose |
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