Document Detail

Effects of physical training on cardiac myosin ATPase activity.
MedLine Citation:
PMID:  236667     Owner:  NLM     Status:  MEDLINE    
Cardiac myosin from rats exercised 90 or 150 min daily for 8 wk was compared with the myosin from the hearts of matched sedentary controls. The Ca++-ATPase activity was increased 17 percent in rats exercised 90 min and 30 percent in rats exercised 150 min daily. In the exercised group 0.18 M KCl increased the myosin ATPase activity by 50 percent but had no effect in the control group. Ethylene glycol activated the Ca++-ATPase in control myosin preparations, but had no significant effect on myosin from conditioned hearts. Heavy meromyosin (HMM) from conditioned hearts had a higher Ca++-ATPase activity than from controls. Fluorescence with 8-anilinonaphthalene sulfonate (ANS) was increased 30 percent in HMM from conditioned hearts. The results suggest that the increased myosin ATPase activity in the hearts of exercised animals may be due to a local conformational change at or near the active site.
A K Bhan; J Scheuer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  228     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-07-18     Completed Date:  1975-07-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1178-82     Citation Subset:  IM; S    
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MeSH Terms
Adenosine Triphosphatases / metabolism*
Anilino Naphthalenesulfonates / diagnostic use
Ethylene Glycols / pharmacology
Hydrogen-Ion Concentration
Myocardium / enzymology*
Myosin Subfragments / metabolism
Myosins / metabolism*
Physical Exertion*
Potassium Chloride / pharmacology
Stimulation, Chemical
Time Factors
Urea / pharmacology
Reg. No./Substance:
0/Anilino Naphthalenesulfonates; 0/Ethylene Glycols; 0/Myosin Subfragments; 57-13-6/Urea; 7440-70-2/Calcium; 7447-40-7/Potassium Chloride; EC 3.6.1.-/Adenosine Triphosphatases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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