| Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes. | |
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MedLine Citation:
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PMID: 8425720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sickle cell trait subjects are potentially at risk with microvascular complications frequently associated with high altitude and extreme exertion. Studies conducted in our laboratory suggest that exposure of sickle cell trait subjects to treadmill exercise resulted in an increase not only in the susceptibility of red blood cells to oxidation but also in the density of RBC membrane. The trend of increased susceptibility of red cells to oxidation as a consequence of exercise was associated with relatively excessive production of H2O2, inefficient breakdown of H2O2 by GSH-Px- and catalase-catalyzed reactions, and inability/failure to show a transitory increase in the activity of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-generating enzymes. |
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Authors:
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S K Das; J E Hinds; R E Hardy; J C Collins; S Mukherjee |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Free radical biology & medicine Volume: 14 ISSN: 0891-5849 ISO Abbreviation: Free Radic. Biol. Med. Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-03-04 Completed Date: 1993-03-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 139-47 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, General Clinical Research Center, Meharry Medical College, Nashville, Tennessee 37208. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Continental Ancestry Group Catalase / blood Erythrocyte Membrane / physiology Erythrocytes / metabolism* Exercise / physiology* Free Radical Scavengers* Glutathione Peroxidase / blood Hemolysis Humans Hydrogen Peroxide / blood* Lipid Peroxidation Male NADP / blood Oxidation-Reduction Sickle Cell Trait / blood* Stress, Physiological / blood*, complications Superoxide Dismutase / blood |
| Grant Support | |
ID/Acronym/Agency:
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GM 08198/GM/NIGMS NIH HHS; RR 00095/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 53-59-8/NADP; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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