Document Detail


Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes.
MedLine Citation:
PMID:  8425720     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sickle cell trait subjects are potentially at risk with microvascular complications frequently associated with high altitude and extreme exertion. Studies conducted in our laboratory suggest that exposure of sickle cell trait subjects to treadmill exercise resulted in an increase not only in the susceptibility of red blood cells to oxidation but also in the density of RBC membrane. The trend of increased susceptibility of red cells to oxidation as a consequence of exercise was associated with relatively excessive production of H2O2, inefficient breakdown of H2O2 by GSH-Px- and catalase-catalyzed reactions, and inability/failure to show a transitory increase in the activity of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-generating enzymes.
Authors:
S K Das; J E Hinds; R E Hardy; J C Collins; S Mukherjee
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  14     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-04     Completed Date:  1993-03-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-47     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, General Clinical Research Center, Meharry Medical College, Nashville, Tennessee 37208.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group
Catalase / blood
Erythrocyte Membrane / physiology
Erythrocytes / metabolism*
Exercise / physiology*
Free Radical Scavengers*
Glutathione Peroxidase / blood
Hemolysis
Humans
Hydrogen Peroxide / blood*
Lipid Peroxidation
Male
NADP / blood
Oxidation-Reduction
Sickle Cell Trait / blood*
Stress, Physiological / blood*,  complications
Superoxide Dismutase / blood
Grant Support
ID/Acronym/Agency:
GM 08198/GM/NIGMS NIH HHS; RR 00095/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Free Radical Scavengers; 53-59-8/NADP; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vasodilatory and toxic effects of spin traps on aerobic cardiac function.
Next Document:  Phosphatidylcholine peroxidation and liver cancer in mice fed a choline-deficient diet with ethionin...