Document Detail


Effects of physical exercise on liver ATP levels in fasted and phosphate-injected rats.
MedLine Citation:
PMID:  10916167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the present study was to investigate the effects of exercise (30 min, 23 m/min, 0% grade) on the hepatic levels of ATP in fasted adrenodemedullated rats, with an intraperitoneal injection of sodium phosphate (Na (2) PO (4 ), 0.91 mM) or saline (NaCl). Sodium phosphate was injected to determine if the postulated decrease in liver ATP during exercise may be changed by providing an excess of phosphate. At the end of exercise, a piece of liver was rapidly freeze clamped and used for the enzymatic determination of ATP levels. Liver ATP, in saline-injected rats, was significantly (P < 0.05) decreased by fasting, compared to fed rats (&Xscr; +/- SE: 3. 21 +/- 0.2 vs 2.86+/- 0.2 micromol/g). Exercise in fasted rats decreased even more the ATP response in liver (2.58 +/- 0.14 micromol/g). Injection of Na (2) PO (4) did not significantly (P > 0. 05) alter the pattern of ATP response following these 3 conditions (3.35 +/- 0.14 vs 3.0 +/-0.12 vs 2.57 +/- 0.1 micromol/g), ATP levels being significantly (P <0.05) decreased by the fast and the exercise in the fasted state. Fasting and exercise resulted in a significant (P < 0.05) decrease in liver glycogen and plasma glucose concentrations and an increase in free fatty acid levels in both NaCl- and Na (2 )PO (4) -injected groups. In both injection conditions, beta-hydroxybutyrate and peripheral insulin concentrations were respectively, increased and decreased (P < 0.05) by fasting, while norepinephrine and portal glucagon were decreased (P > 0.05) following exercise. The main effect of the injection of Na ( 2) PO (4) was a stimulation (P < 0.05) of peripheral glucagon response following exercise. It is concluded that exercise results in a decrease in liver ATP levels even in fasted rats and that this decrease is not corrected by Na (2 )PO( 4) administration. The decreased liver ATP levels might be involved in the metabolic adaptations to exercise.
Authors:
A Ghanbari-Niaki; R Bergeron; M G Latour; J M Lavoie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of physiology and biochemistry     Volume:  107     ISSN:  1381-3455     ISO Abbreviation:  Arch. Physiol. Biochem.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-08-30     Completed Date:  2000-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9510153     Medline TA:  Arch Physiol Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  393-402     Citation Subset:  IM    
Affiliation:
Département de kinésiologie, Université de Montréal, Montréal, QUE, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism*
Adrenal Medulla / surgery
Animals
Blood Glucose / metabolism
Chromatography, High Pressure Liquid
Epinephrine / metabolism
Fasting / metabolism*
Glucagon / metabolism
Hepatic Veins
Insulin / metabolism
Lactic Acid / metabolism
Liver / metabolism*
Liver Glycogen / metabolism
Male
Norepinephrine / metabolism
Phosphates / metabolism,  pharmacology*
Physical Conditioning, Animal / physiology*
Rats
Rats, Sprague-Dawley
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Liver Glycogen; 0/Phosphates; 0/Triglycerides; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 56-65-5/Adenosine Triphosphate; 7632-05-5/sodium phosphate; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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