| Effects of physical exercise on liver ATP levels in fasted and phosphate-injected rats. | |
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MedLine Citation:
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PMID: 10916167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present study was to investigate the effects of exercise (30 min, 23 m/min, 0% grade) on the hepatic levels of ATP in fasted adrenodemedullated rats, with an intraperitoneal injection of sodium phosphate (Na (2) PO (4 ), 0.91 mM) or saline (NaCl). Sodium phosphate was injected to determine if the postulated decrease in liver ATP during exercise may be changed by providing an excess of phosphate. At the end of exercise, a piece of liver was rapidly freeze clamped and used for the enzymatic determination of ATP levels. Liver ATP, in saline-injected rats, was significantly (P < 0.05) decreased by fasting, compared to fed rats (𝒳 +/- SE: 3. 21 +/- 0.2 vs 2.86+/- 0.2 micromol/g). Exercise in fasted rats decreased even more the ATP response in liver (2.58 +/- 0.14 micromol/g). Injection of Na (2) PO (4) did not significantly (P > 0. 05) alter the pattern of ATP response following these 3 conditions (3.35 +/- 0.14 vs 3.0 +/-0.12 vs 2.57 +/- 0.1 micromol/g), ATP levels being significantly (P <0.05) decreased by the fast and the exercise in the fasted state. Fasting and exercise resulted in a significant (P < 0.05) decrease in liver glycogen and plasma glucose concentrations and an increase in free fatty acid levels in both NaCl- and Na (2 )PO (4) -injected groups. In both injection conditions, beta-hydroxybutyrate and peripheral insulin concentrations were respectively, increased and decreased (P < 0.05) by fasting, while norepinephrine and portal glucagon were decreased (P > 0.05) following exercise. The main effect of the injection of Na ( 2) PO (4) was a stimulation (P < 0.05) of peripheral glucagon response following exercise. It is concluded that exercise results in a decrease in liver ATP levels even in fasted rats and that this decrease is not corrected by Na (2 )PO( 4) administration. The decreased liver ATP levels might be involved in the metabolic adaptations to exercise. |
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Authors:
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A Ghanbari-Niaki; R Bergeron; M G Latour; J M Lavoie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of physiology and biochemistry Volume: 107 ISSN: 1381-3455 ISO Abbreviation: Arch. Physiol. Biochem. Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-08-30 Completed Date: 2000-08-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9510153 Medline TA: Arch Physiol Biochem Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 393-402 Citation Subset: IM |
Affiliation:
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Département de kinésiologie, Université de Montréal, Montréal, QUE, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism* Adrenal Medulla / surgery Animals Blood Glucose / metabolism Chromatography, High Pressure Liquid Epinephrine / metabolism Fasting / metabolism* Glucagon / metabolism Hepatic Veins Insulin / metabolism Lactic Acid / metabolism Liver / metabolism* Liver Glycogen / metabolism Male Norepinephrine / metabolism Phosphates / metabolism, pharmacology* Physical Conditioning, Animal / physiology* Rats Rats, Sprague-Dawley Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Liver Glycogen; 0/Phosphates; 0/Triglycerides; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 56-65-5/Adenosine Triphosphate; 7632-05-5/sodium phosphate; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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