Document Detail

Effects of physical conditioning on lipids and arachidonic acid metabolites in untrained boys: a longitudinal study.
MedLine Citation:
PMID:  16900233     Owner:  NLM     Status:  MEDLINE    
In addition to a variety of lipids, 2 products of the arachidonic acid cascade, prostacyclin and thromboxane, are involved in the pathogenesis of atherosclerosis as a result of their effects on platelet function and on the vascular endothelium. The aim of the present investigation was to ascertain if a sub-maximal 8 week endurance training period followed by a 4 week detraining period would have any effects on high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG), 2,3-dinor-6-keto-prostaglandin F(1alpha) (2,3-dinor-6-keto-PGF(1alpha)), the urinary metabolite of prostacyclin, 2,3-dinor-thromboxane B2 (2,3-dinor-TXB2), the urinary metabolite of thromboxane, and the ratios of TC to HDL-C and of 2,3 dinor-6-keto-PGF(1alpha) to 2,3-dinor-TXB2. Thirty-eight boys aged 10-14 were randomly divided into exercise (n = 21) and control (n = 17) groups. The exercise group trained on a bicycle ergometer 4 times/week, 1 h/session, at 80% of their physical working capacity at a heart rate of 170 beats/min (PWC(170)), for 8 weeks. The control group did not participate in any specific physical exercise program. The results showed that relative to the control group, the exercise group had a significant increase in HDL-C and 2,3-dinor-6-keto-PGF(1alpha) concentrations at the end of the 4th (p < 0.05 and p < 0.001, respectively) and the 8th week (p < 0.01 and p < 0.001) of training, respectively; a significant increase in the 2,3 dinor-6-keto-PGF(1alpha) - 2,3-dinor-TXB2 ratio (p < 0.05 and p < 0.01 at the same intervals); a significant decrease in TG at the end of the 8th week of training (p < 0.05); and a significant decrease in the TC--HDL-C ratio at the end of the 4th (p < 0.05) and 8th weeks of training (p < 0.001).
Apostolos Thomas Stergioulas; Dimitrios Konstantinos Filippou
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  31     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-10     Completed Date:  2006-10-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  432-41     Citation Subset:  IM    
Peloponnese University, Faculty of Human Movement and Quality of Life, Lyssandrou 5, 23100 Sparta, Greece.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / analogs & derivatives,  blood
Arachidonic Acid / blood*
Body Weight
Cholesterol / blood
Cholesterol, HDL / blood
Heart Rate
Lipids / blood*
Longitudinal Studies
Physical Endurance / physiology
Physical Exertion / physiology
Physical Fitness / physiology*
Thromboxane B2 / analogs & derivatives,  blood
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, HDL; 0/Lipids; 0/Triglycerides; 506-32-1/Arachidonic Acid; 54397-85-2/Thromboxane B2; 57-88-5/Cholesterol; 58962-34-8/6-Ketoprostaglandin F1 alpha; 63250-09-9/2,3-dinor-thromboxane B2; 64700-71-6/2,3-dinor-6-ketoprostaglandin F1alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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