| Effects of physical conditioning on lipids and arachidonic acid metabolites in untrained boys: a longitudinal study. | |
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MedLine Citation:
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PMID: 16900233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In addition to a variety of lipids, 2 products of the arachidonic acid cascade, prostacyclin and thromboxane, are involved in the pathogenesis of atherosclerosis as a result of their effects on platelet function and on the vascular endothelium. The aim of the present investigation was to ascertain if a sub-maximal 8 week endurance training period followed by a 4 week detraining period would have any effects on high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG), 2,3-dinor-6-keto-prostaglandin F(1alpha) (2,3-dinor-6-keto-PGF(1alpha)), the urinary metabolite of prostacyclin, 2,3-dinor-thromboxane B2 (2,3-dinor-TXB2), the urinary metabolite of thromboxane, and the ratios of TC to HDL-C and of 2,3 dinor-6-keto-PGF(1alpha) to 2,3-dinor-TXB2. Thirty-eight boys aged 10-14 were randomly divided into exercise (n = 21) and control (n = 17) groups. The exercise group trained on a bicycle ergometer 4 times/week, 1 h/session, at 80% of their physical working capacity at a heart rate of 170 beats/min (PWC(170)), for 8 weeks. The control group did not participate in any specific physical exercise program. The results showed that relative to the control group, the exercise group had a significant increase in HDL-C and 2,3-dinor-6-keto-PGF(1alpha) concentrations at the end of the 4th (p < 0.05 and p < 0.001, respectively) and the 8th week (p < 0.01 and p < 0.001) of training, respectively; a significant increase in the 2,3 dinor-6-keto-PGF(1alpha) - 2,3-dinor-TXB2 ratio (p < 0.05 and p < 0.01 at the same intervals); a significant decrease in TG at the end of the 8th week of training (p < 0.05); and a significant decrease in the TC--HDL-C ratio at the end of the 4th (p < 0.05) and 8th weeks of training (p < 0.001). |
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Authors:
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Apostolos Thomas Stergioulas; Dimitrios Konstantinos Filippou |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme Volume: 31 ISSN: 1715-5312 ISO Abbreviation: - Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-10 Completed Date: 2006-10-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101264333 Medline TA: Appl Physiol Nutr Metab Country: Canada |
Other Details:
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Languages: eng Pagination: 432-41 Citation Subset: IM |
Affiliation:
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Peloponnese University, Faculty of Human Movement and Quality of Life, Lyssandrou 5, 23100 Sparta, Greece. asterg@uop.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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analogs & derivatives,
blood Adolescent Arachidonic Acid / blood* Body Weight Child Cholesterol / blood Cholesterol, HDL / blood Heart Rate Humans Lipids / blood* Longitudinal Studies Male Physical Endurance / physiology Physical Exertion / physiology Physical Fitness / physiology* Thromboxane B2 / analogs & derivatives, blood Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Lipids; 0/Triglycerides; 506-32-1/Arachidonic Acid; 54397-85-2/Thromboxane B2; 57-88-5/Cholesterol; 58962-34-8/6-Ketoprostaglandin F1 alpha; 63250-09-9/2,3-dinor-thromboxane B2; 64700-71-6/2,3-dinor-6-ketoprostaglandin F1alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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