Document Detail


Effects of photoperiod and food restriction on the reproductive physiology of female California mice.
MedLine Citation:
PMID:  22245263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many temperate-zone animals use changes in photoperiod to time breeding. Shorter term cues, like food availability, are integrated with photoperiod to adjust reproductive timing under unexpected conditions. Many mice of the genus Peromyscus breed in the summer. California mice (Peromyscus californicus), however, can breed year round, but tend to begin breeding in the winter. Glial cells may be involved in transduction of environmental signals that regulate gonadotrophin releasing hormone I (GnRH) activity. We examined the effects of diet and photoperiod on reproduction in female California mice. Mice placed on either short days (8L:16D) or long days (16L:8D) were food restricted (80% of normal intake) or fed ad libitum. Short day-food restricted mice showed significant regression of the reproductive system. GnRH-immunoreactivity was increased in the tuberal hypothalamus of long day-food restricted mice. This may be associated with the sparing effect long days have when mice are food restricted. The number of GFAP-immunoreactive fibers in proximity to GnRH nerve terminals correlated negatively with uterine size in ad libitum but not food restricted mice, suggesting diet may alter glial regulation of the reproductive axis. There was a trend towards food restriction increasing uterine expression of c-fos mRNA, an estrogen dependent gene. Similar to other seasonally breeding rodents, short days render the reproductive system of female California mice more susceptible to effects of food restriction. This may be vestigial, or it may have evolved to mitigate consequences of unexpectedly poor winter food supplies.
Authors:
Michael Q Steinman; Jennifer A Knight; Brian C Trainor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-05
Journal Detail:
Title:  General and comparative endocrinology     Volume:  176     ISSN:  1095-6840     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-23     Completed Date:  2012-11-06     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Estrogen Receptor alpha / genetics,  physiology
Female
Food Deprivation / physiology*
Gonadotropin-Releasing Hormone / physiology*
Hypothalamus / cytology,  physiology*
Immunohistochemistry / veterinary
Mice
Nerve Tissue Proteins / genetics,  physiology
Neuroglia / physiology
Peromyscus / physiology*
Photoperiod
Proto-Oncogene Proteins c-fos / genetics,  physiology
RNA, Messenger / chemistry,  genetics
Random Allocation
Real-Time Polymerase Chain Reaction / veterinary
Reproduction / physiology*
Statistics, Nonparametric
Uterus / physiology
Grant Support
ID/Acronym/Agency:
F31 MH095253/MH/NIMH NIH HHS; F31 MH095253-01/MH/NIMH NIH HHS; F31 MH095253-02/MH/NIMH NIH HHS; R01 MH085069/MH/NIMH NIH HHS; R01 MH085069-01/MH/NIMH NIH HHS; R01 MH085069-04/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/Nerve Tissue Proteins; 0/Proto-Oncogene Proteins c-fos; 0/RNA, Messenger; 0/glial fibrillary astrocytic protein, mouse; 33515-09-2/Gonadotropin-Releasing Hormone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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