| Effects of photoperiod and food restriction on the reproductive physiology of female California mice. | |
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MedLine Citation:
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PMID: 22245263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many temperate-zone animals use changes in photoperiod to time breeding. Shorter term cues, like food availability, are integrated with photoperiod to adjust reproductive timing under unexpected conditions. Many mice of the genus Peromyscus breed in the summer. California mice (Peromyscus californicus), however, can breed year round, but tend to begin breeding in the winter. Glial cells may be involved in transduction of environmental signals that regulate gonadotrophin releasing hormone I (GnRH) activity. We examined the effects of diet and photoperiod on reproduction in female California mice. Mice placed on either short days (8L:16D) or long days (16L:8D) were food restricted (80% of normal intake) or fed ad libitum. Short day-food restricted mice showed significant regression of the reproductive system. GnRH-immunoreactivity was increased in the tuberal hypothalamus of long day-food restricted mice. This may be associated with the sparing effect long days have when mice are food restricted. The number of GFAP-immunoreactive fibers in proximity to GnRH nerve terminals correlated negatively with uterine size in ad libitum but not food restricted mice, suggesting diet may alter glial regulation of the reproductive axis. There was a trend towards food restriction increasing uterine expression of c-fos mRNA, an estrogen dependent gene. Similar to other seasonally breeding rodents, short days render the reproductive system of female California mice more susceptible to effects of food restriction. This may be vestigial, or it may have evolved to mitigate consequences of unexpectedly poor winter food supplies. |
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Authors:
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Michael Q Steinman; Jennifer A Knight; Brian C Trainor |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-01-05 |
Journal Detail:
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Title: General and comparative endocrinology Volume: 176 ISSN: 1095-6840 ISO Abbreviation: Gen. Comp. Endocrinol. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-23 Completed Date: 2012-11-06 Revised Date: 2013-05-22 |
Medline Journal Info:
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Nlm Unique ID: 0370735 Medline TA: Gen Comp Endocrinol Country: United States |
Other Details:
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Languages: eng Pagination: 391-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Molecular, Cellular and Integrative Physiology Graduate Group, University of California, Davis, CA 95616, USA. mqsteinman@ucdavis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Estrogen Receptor alpha / genetics, physiology Female Food Deprivation / physiology* Gonadotropin-Releasing Hormone / physiology* Hypothalamus / cytology, physiology* Immunohistochemistry / veterinary Mice Nerve Tissue Proteins / genetics, physiology Neuroglia / physiology Peromyscus / physiology* Photoperiod Proto-Oncogene Proteins c-fos / genetics, physiology RNA, Messenger / chemistry, genetics Random Allocation Real-Time Polymerase Chain Reaction / veterinary Reproduction / physiology* Statistics, Nonparametric Uterus / physiology |
| Grant Support | |
ID/Acronym/Agency:
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F31 MH095253-01/MH/NIMH NIH HHS; F31 MH095253-02/MH/NIMH NIH HHS; R01 MH085069/MH/NIMH NIH HHS; R01 MH085069-01/MH/NIMH NIH HHS; R01 MH085069-04/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Estrogen Receptor alpha; 0/Nerve Tissue Proteins; 0/Proto-Oncogene Proteins c-fos; 0/RNA, Messenger; 0/glial fibrillary astrocytic protein, mouse; 33515-09-2/Gonadotropin-Releasing Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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