| Effects of phospholipids on the in vitro percutaneous penetration of prednisolone and analysis of mechanism by using attenuated total reflectance-Fourier transform infrared spectroscopy. | |
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MedLine Citation:
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PMID: 8923329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effects of 10 phospholipids on the in vitro percutaneous penetration of prednisolone (PR) through the dorsal skin of guinea pigs. A marked enhancing effect of PR penetration was observed in the presence of phospholipids that have unsaturated acyl chains. A maximum of 68-fold enhancement was observed compared to that of control. On the contrary, phospholipids that have saturated acyl chains did not significantly increase the amount of PR passing to the receptor side. Attenuated total reflectance-Fourier transform infrared spectroscopy was used to monitor the outer several microns of stratum corneum (SC) surface. It was observed that phospholipids that have unsaturated acyl chains induced higher and broader absorbance shifts in the C-H bond stretching region while phospholipids that have saturated acyl chains induced lower and sharper absorbance shifts in the C-H bond stretching region. A significant parallel between the amount of PR penetrated and the lipid-chain fluidity of the SC was found. These results suggest that phospholipids may influence the percutaneous penetration of PR by changing the lipid-chain fluidity of the SC. |
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Authors:
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Y Yokomizo; H Sagitani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 85 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-02-18 Completed Date: 1997-02-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1220-6 Citation Subset: IM |
Affiliation:
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Pharmaceutical Research Laboratories, POLA R&D Laboratories, POLA Corporation, Yokohama, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Guinea Pigs Male Phospholipids / pharmacology* Prednisolone / pharmacokinetics* Skin / metabolism Skin Absorption / drug effects* Spectroscopy, Fourier Transform Infrared |
| Chemical | |
Reg. No./Substance:
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0/Phospholipids; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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