Document Detail

Effects of phosphate loading on metabolic and myocardial responses to maximal and endurance exercise.
MedLine Citation:
PMID:  1299483     Owner:  NLM     Status:  MEDLINE    
Six trained male cyclists and triathletes participated in a double blind study to determine the effects of phosphate loading on maximal and endurance exercise performance. Subjects ingested either 1 gm of tribasic sodium phosphate or a glucose placebo four times daily for 3 days prior to performing either an incremental maximal cycling test or a simulated 40-km time trial on a computerized race simulator. They continued the supplementation protocol for an additional day and then performed the remaining maximal or performance exercise test. Subjects observed a 17-day washout period between testing sessions and repeated the experiment with the alternate supplement regimen in identical fashion. Metabolic data were collected at 15-sec intervals while venous blood samples and 2D-echocardiographic data were collected during each stage of exercise during the maximal exercise test and at 8-km intervals during the 40-km time trial. Results indicate that phosphate loading attenuated anaerobic threshold, increased myocardial ejection fraction and fractional shortening, increased maximal oxidative capacity, and enhanced endurance performance in competitive cyclists and triathletes.
R B Kreider; G W Miller; D Schenck; C W Cortes; V Miriel; C T Somma; P Rowland; C Turner; D Hill
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of sport nutrition     Volume:  2     ISSN:  1050-1606     ISO Abbreviation:  Int J Sport Nutr     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1993-05-20     Completed Date:  1993-05-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9307702     Medline TA:  Int J Sport Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  20-47     Citation Subset:  IM    
Dept. of HPER, Old Dominion University, Norfolk, VA 23529-0196.
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MeSH Terms
Double-Blind Method
Exercise / physiology*
Heart / drug effects,  physiology*
Hemoglobins / metabolism
Metabolism / drug effects*
Oxygen Consumption
Phosphates / administration & dosage*,  blood,  pharmacology
Physical Endurance / physiology*
Random Allocation
Reg. No./Substance:
0/Hemoglobins; 0/Phosphates; 0/Placebos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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