Document Detail

Effects of phenytoin on regional cerebral blood flow, electroencephalogram, and electrolyte contents in cerebral blood and cerebral cortex following total cerebral ischemia in dogs.
MedLine Citation:
PMID:  6616766     Owner:  NLM     Status:  MEDLINE    
To study the protective effect of phenytoin on postischemic brain damage, total cerebral ischemia was produced for 8-12 min (aortic occlusion balloon catheter method) in 36 adult mongrel dogs. The regional cerebral blood flow (rCBF), sodium:potassium ratio in the cerebral cortex, electroencephalogram (EEG), and plasma electrolytes in the superior sagittal sinus blood were examined before ischemia and during the acute stage up to 120 min after recirculation in the control and phenytoin-treated groups. Measurement of rCBF (microsphere method) indicated easing of postischemic hypoperfusion of the cerebral cortex. The time from total cerebral ischemia to EEG electrical silence was significantly prolonged, and recovery of the electrical activity after recirculation was hastened. The increase in plasma potassium concentration in the superior sagittal sinus tended to be suppressed immediately after recirculation, and the sodium:potassium ratio in the cerebral cortex was lowered. Phenytoin increased the rCBF in the cerebral cortex, hastened the recovery of electrical activity, and stabilized the water and electrolyte balance in the cerebral cortex, suggesting some protecting effect on total cerebral ischemia.
A Fukuda; H Tabuse; N Ihara; J Tanabe; H Ikeda; A Kohama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulatory shock     Volume:  10     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1983  
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  341-50     Citation Subset:  IM    
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MeSH Terms
Brain Ischemia / physiopathology*
Cerebral Cortex / analysis,  drug effects*
Cerebrovascular Circulation / drug effects*
Electrolytes / analysis*,  blood
Phenytoin / pharmacology*
Reg. No./Substance:
0/Electrolytes; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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