Document Detail

Effects of phenoxybenzamine in shock due to myocardial infarction.
MedLine Citation:
PMID:  5762277     Owner:  NLM     Status:  MEDLINE    
Treatment of cardiogenic shock with vasodilator drugs has been advocated on the basis of experimental work showing that a fall in peripheral resistance allows the cardiac output to increase without any increase in cardiac work.Seven patients suffering from shock secondary to myocardial infarction were treated with phenoxybenzamine. In two cases there was dramatic improvement in the signs and symptoms of shock, but in six of the seven cases there were severe adverse effects on respiration, including the development of wheezing and rales and rhonchi.
J F Riordan; G Walters
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  1     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1969 Jan 
Date Detail:
Created Date:  1969-02-25     Completed Date:  1969-02-25     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiac Output / drug effects
Middle Aged
Myocardial Infarction / complications*
Phenoxybenzamine / adverse effects*,  therapeutic use
Respiration / drug effects
Shock / drug therapy*,  etiology
Vascular Resistance / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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