Document Detail


Effects of pharyngeal muscle activation on airway pressure-area relationships.
MedLine Citation:
PMID:  12359656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fiberoptic imaging in an isolated, sealed upper airway was performed in 10 decerebrate cats to determine the effect of pharyngeal muscle activation on airway pressure-area relationships. Bilateral cuff electrodes stimulated the distal cut ends of the following nerves: medial and lateral hypoglossus, glossopharyngeus, and pharyngeal branch of vagus. At given intraluminal pressures ranging from +6 to -6 cm H2O, cross-sectional area was measured in the rostral oropharynx, velopharynx, and caudal oropharynx, with and without nerve stimulation. A mixed model analysis of variance indicated a relatively constant increase in area across the pressure range with glossopharyngeal stimulation at any given level. Significant interactions between pressure and stimulation were present in the rostral oropharynx with medial hypoglossus stimulation and in the caudal oropharynx with independent and combined hypoglossal branch stimulation and pharyngeal branch of vagus stimulation. With stimulation of the hypoglossal nerves, greater increases in area in these regions occurred in the lower pressure ranges. Stimulation of the pharyngeal branch of the vagus caused a greater decrease in area at the higher pressure ranges in the caudal oropharynx and velopharynx. The results indicate that the mechanical effects of pharyngeal muscle activation depend not only on the region and muscles activated but also on the intraluminal pressure.
Authors:
Samuel T Kuna; Michael J Brennick
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  166     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-02     Completed Date:  2002-11-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  972-7     Citation Subset:  AIM; IM    
Affiliation:
Pulmonary, Allergy, and Critical Care Division, Department of Internal Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA, USA. skuna@mail.med.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Cats
Electric Stimulation
Glossopharyngeal Nerve / physiology
Hypoglossal Nerve / physiology
Models, Animal
Pharyngeal Muscles / blood supply*,  physiology*
Predictive Value of Tests
Pulmonary Wedge Pressure / physiology*
Grant Support
ID/Acronym/Agency:
HL-27520/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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