Document Detail

Effects of pharmacological and non-pharmacological interventions.
MedLine Citation:
PMID:  20500609     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Asthma is recognised as a condition with variable airway obstruction with pathophysiological features that include activation of a wide range of inflammatory and structural cells. Additionally, structural changes in the airways have been demonstrated. This includes increased thickening of components in the basement membrane region, increased smooth muscle mass, increased vascularisation and many other events that is often referred to as remodelling of the airways. These processes and the underlying mechanisms have attracted considerable attention. METHODS AND RESULTS: This review describes the different interventive approaches that have been tried in order to improve asthma control and affect the underlying pathophysiological pathways. These include elimination of harmful environmental and occupational exposures, a wide range of pharmacological agents as well as bronchial thermoplasty. The existing evidence for effects on airway inflammation and airway remodelling is discussed in relationship to mechanistic aspects and short- and long-term outcome. CONCLUSION: It is expected that modulation of the asthmatic airway remodelling will become an even more important endpoint in the near future.
Thomas Sandström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The clinical respiratory journal     Volume:  4 Suppl 1     ISSN:  1752-699X     ISO Abbreviation:  Clin Respir J     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101315570     Medline TA:  Clin Respir J     Country:  England    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  IM    
Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå, Sweden.
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MeSH Terms
Airway Remodeling*
Anti-Asthmatic Agents / therapeutic use*
Asthma / drug therapy*,  pathology*
Treatment Outcome
Reg. No./Substance:
0/Anti-Asthmatic Agents

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