Document Detail

Effects of peroxisome proliferators on the thymus and spleen of mice.
MedLine Citation:
PMID:  11091278     Owner:  NLM     Status:  MEDLINE    
The effects of peroxisome proliferators on the immune system of male C57B1/6 mice have been investigated. Significant atrophy of the thymus and spleen was observed in animals treated with potent peroxisome proliferators (e.g. perfluorooctanoic acid (PFOA), di(2-ethylhexyl)phthalate (DEHP), Wy-14643 and nafenopin), whereas the effects of a moderate peroxisome proliferator (i.e. acetylsalicylic acid (ASA)) were relatively weak. The time course of thymic and splenic atrophy caused by PFOA was found to resemble the time course of the increase in liver weight and of peroxisome proliferation. Analysis of the numbers and phenotypes of thymocytes and splenocytes from PFOA-treated mice revealed the following: (i) the numbers of thymocytes and splenocytes were decreased > 90% and about 50%, respectively, by PFOA treatment; (ii) although all populations of thymocytes were decreased, the immature CD4+CD8+ population was decreased most dramatically; (iii) the numbers of both T and B cells in the spleen were decreased by PFOA treatment. Analysis of the cell cycle of thymocytes indicated that the thymic atrophy caused by PFOA in mice results, at least in part, from inhibition of thymocyte proliferation. Interestingly, in vitro exposure to PFOA for up to 24 h did not produce analogous effects in either thymocytes or splenocytes. Thus, the thymic and splenic atrophy caused by PFOA appears to involve an indirect pathway.
Q Yang; Y Xie; J W Depierre
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  122     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-01     Completed Date:  2000-12-14     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
Department of Biochemistry, Stockholm University, Sweden.
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MeSH Terms
Aspirin / toxicity
B-Lymphocytes / drug effects,  immunology,  pathology
Caprylates / toxicity
Cell Cycle / drug effects
Cell Division / drug effects
DNA / metabolism
Diethylhexyl Phthalate / toxicity
Fluorocarbons / toxicity
Mice, Inbred C57BL
Nafenopin / toxicity
Peroxisome Proliferators / toxicity*
Pyrimidines / toxicity
Spleen / drug effects*,  immunology,  pathology
T-Lymphocytes / drug effects,  immunology,  pathology
Thymus Gland / drug effects*,  immunology,  pathology
Reg. No./Substance:
0/Caprylates; 0/Fluorocarbons; 0/Peroxisome Proliferators; 0/Pyrimidines; 117-81-7/Diethylhexyl Phthalate; 335-67-1/perfluorooctanoic acid; 3771-19-5/Nafenopin; 50-78-2/Aspirin; 86C4MRT55A/pirinixic acid; 9007-49-2/DNA

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