| Effects of peroxisome proliferator activated receptor-gamma 2 gene Pro12Ala polymorphism on fasting blood lipids: A meta-analysis. | |
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MedLine Citation:
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PMID: 21185561 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Results from the published studies on the association of peroxisome proliferator activated receptor-gamma 2 (PPARγ2) Pro12Ala polymorphism with blood lipids are conflicting. In this meta-analysis, we investigated the association of the Pro12Ala polymorphism with total cholesterol, triglycerides, low density lipoprotein cholesterol, and high-density lipoprotein cholesterol. METHODS: 74 studies with 52,998 subjects were included in this meta-analysis. Dominant model and additive model were used for this meta-analysis. RESULTS: We did not detect significant overall association of the Pro12Ala polymorphism with total cholesterol, low density lipoprotein cholesterol, or high-density lipoprotein cholesterol (P>0.05). Under dominant model, significant association between the PPARγ2 Pro12Ala polymorphism and increased blood TC in male subjects was detected: standardized mean difference=0.10, 95% confidence interval (0.02, 0.22), P=0.02, P(heterogeneity)=0.14. We found a marginal association of the Pro12Ala polymorphism with increased HDL-C in healthy subjects under dominant model: standardized mean difference=0.10, 95% confidence interval (-0.00, 0.20), P=0.06, P(heterogeneity)=0.96. We also found subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians: for analysis including the outlier studies: SMD=-0.40, 95% CI (-0.76, -0.05), P=0.02, P(heterogeneity)<0.00001, and for analysis excluding the outlier studies: SMD=-0.23, 95% CI (-0.39, -0.06), P=0.006, P(heterogeneity)=0.86. CONCLUSIONS: Our meta-analysis suggests that, compared with non-carriers, carriers of Ala allele have significant increased blood TC in male subjects, and marginally significant increased blood HDL-C in healthy subjects. Our meta-analysis also supports that subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians. |
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Authors:
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Xiao Huang; Jiangpei Zhao; Tongfeng Zhao |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-8 |
Journal Detail:
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Title: Atherosclerosis Volume: - ISSN: 1879-1484 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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College of Life Sciences, Zhejiang University, Hangzhou 310000, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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