Document Detail

Effects of perioperative central neuraxial analgesia on outcome after coronary artery bypass surgery: a meta-analysis.
MedLine Citation:
PMID:  15220785     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Perioperative central neuraxial analgesia may improve outcome after coronary artery bypass surgery due to attenuation of stress response and superior analgesia. METHODS: MEDLINE and other databases were searched for randomized controlled trials in patients undergoing coronary artery bypass surgery with cardiopulmonary bypass who were randomized to either general anesthesia (GA) versus general anesthesia-thoracic epidural analgesia (TEA) or general anesthesia-intrathecal analgesia (IT). RESULTS: Fifteen trials enrolling 1178 patients were included for TEA analysis. TEA did not affect incidences of mortality (0.7% TEA vs. 0.3% GA) or myocardial infarction (2.3% TEA vs. 3.4% GA). TEA significantly reduced the risk of dysrhythmias with an odds ratio of 0.52, pulmonary complications with an odds ratio of 0.41, and time to tracheal extubation by 4.5 h and reduced analog pain scores at rest by 7.8 mm and with activity by 11.6 mm. Seventeen trials enrolling 668 patients were included for IT analysis. IT had no significant effect on incidences of mortality (0.3% IT vs. 0.6% GA), myocardial infarction (3.9% IT vs. 5.7% GA), dysrhythmias (24.8% vs. 29.1%), nausea/vomiting (31.3% vs. 28.5%), or time to tracheal extubation (10.4 h IT vs. 10.9 h GA). IT modestly decreased systemic morphine use by 11 mg and decreased pain scores by 16 mm. IT significantly increased the incidence of pruritus (10% vs. 2.5%). CONCLUSIONS: There were no differences in the rates of mortality or myocardial infarction after coronary artery bypass grafting with central neuraxial analgesia. There were associated improvements in faster time until tracheal extubation, decreased pulmonary complications and cardiac dysrhythmias, and reduced pain scores.
Spencer S Liu; Brian M Block; Christopher L Wu
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  101     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-28     Completed Date:  2004-07-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-61     Citation Subset:  AIM; IM    
Department of Anesthesiology, Virginia Mason Medical Center and the University of Washington, Seattle, Washington 98111, USA.
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MeSH Terms
Analgesia, Epidural
Anesthesia, General / adverse effects*,  mortality
Anesthesia, Intravenous
Anesthesia, Spinal
Arrhythmias, Cardiac / epidemiology,  etiology,  mortality
Central Nervous System*
Clinical Trials as Topic
Coronary Artery Bypass* / adverse effects,  mortality
Injections, Spinal
Lung Diseases / epidemiology,  etiology,  mortality
Myocardial Infarction / epidemiology,  etiology,  mortality
Nerve Block / adverse effects*,  mortality
Pain, Postoperative / epidemiology
Perioperative Care*
Postoperative Nausea and Vomiting / epidemiology
Randomized Controlled Trials as Topic
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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