| Effects of perinatal oxycodone exposure on the response to CRH in late adolescent rats. | |
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MedLine Citation:
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PMID: 18255259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We hypothesized that prenatal oxycodone exposure suppresses the Hypothalamic-Pituitary-Adrenal (HPA) response to stress in late adolescence. Dark Agouti rats were given either intravenous oxycodone or vehicle (controls, CON) daily from gestation day 8 until postnatal day (PD) 5. At PD 45, the male and female offspring received intravenously either ovine corticotropin releasing hormone (CRH) or saline. Plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels were determined before, and 15, 30, and 60 min after injection. Prenatal oxycodone had no effect on baseline ACTH values; CRH elicited a greater ACTH response than saline. In males, prenatal oxycodone delayed and enhanced the peak ACTH response to CRH, but had no effect in females. The CORT response to CRH was not different between oxycodone and CON; however mean CORT levels in females were significantly higher than those in males at baseline and after stimulation. These results demonstrate that prenatal oxycodone increases pituitary response to CRH in late adolescent male rats, but not in females. The absence of an enhanced adrenal response in oxycodone-exposed males suggests either desensitization or maximal adrenal response to a high CRH dose. The mechanisms of postnatal sex-specific HPA dysregulation following prenatal oxycodone remain to be elucidated. |
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Authors:
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Thitinart Sithisarn; Henrietta S Bada; Hongying Dai; Christopher R Reinhardt; David C Randall; Sandra J Legan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-01-11 |
Journal Detail:
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Title: Neurotoxicology and teratology Volume: 30 ISSN: 0892-0362 ISO Abbreviation: Neurotoxicol Teratol Publication Date: 2008 Mar-Apr |
Date Detail:
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Created Date: 2008-02-25 Completed Date: 2008-05-28 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 8709538 Medline TA: Neurotoxicol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 118-24 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Chandler Medical Center, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood Analgesics, Opioid / toxicity* Animals Body Weight / drug effects Corticotropin-Releasing Hormone / pharmacology* Data Interpretation, Statistical Female Hydrocortisone / blood Hypothalamo-Hypophyseal System / drug effects, growth & development* Litter Size / drug effects Male Oxycodone / toxicity* Parturition / drug effects Pregnancy Prenatal Exposure Delayed Effects* Rats |
| Grant Support | |
ID/Acronym/Agency:
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K30 HL 04163/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 50-23-7/Hydrocortisone; 76-42-6/Oxycodone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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