Document Detail

Effects of perinatal coexposure to methylmercury and polychlorinated biphenyls on neurobehavioral development in mice.
MedLine Citation:
PMID:  17992516     Owner:  NLM     Status:  MEDLINE    
Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are environmental pollutants that cause neurobehavioral deficits in humans. Because exposures to MeHg and PCBs occur through fish consumption, it is necessary to clarify the effects of the interaction of the two pollutants. Therefore, we investigated the effects of perinatal exposure to MeHg and PCBs on the neurobehavioral development in mice. Female mice (C57BL/6Cr) were divided into four groups according to the type of exposure: (1) vehicle control, (2) MeHg alone, (3) PCBs alone, and (4) MeHg + PCBs. The MeHg-exposed groups were fed with a diet containing 5 ppm MeHg (as Hg), from 4 weeks before mating, throughout pregnancy, and lactation. The PCB-exposed groups were given a commercial mixture of PCBs, Aroclor 1,254, at 18 mg/kg body weight in corn oil by gavage every 3 days from day 5 after breeding and continued until postnatal day (PND) 20. Before weaning, an assessment of eye opening showed the interactive effects between MeHg and PCBs on PND 12: The coexposure group showed a similar response to the control group, whereas the MeHg- and PCB-exposed groups showed a high response than the former two groups. We also observed delay in development of grasp reflex by MeHg exposure on PNDs 12 and 14. When the offspring mice were 8 weeks old, the group exposed to PCBs alone showed increases in the frequencies of excrement defecation and urine traces in an open-field test. Analysis of the latency revealed the antagonistic interaction between the MeHg and PCBs: The latency increased by either MeHg or PCB exposure was decreased by coexposure. Treatment with MeHg decreased the distance walked by the mice, and MeHg interacted with PCBs. Moris' water maze test showed that the MeHg-treated mice took a long time to reach the submerged platform; however, this MeHg exposure showed no interaction with PCB exposure. The spontaneous locomotion activity of the mice was not affected by the chemical exposure at 9 weeks of age. These behavioral changes were not accompanied by any histopathological changes at the levels of the frontal cortex-caudoputamen, hippocampus-amygdala, brainstem and cerebellum. These results show that perinatal coexposure to MeHg and PCBs produces no additive or synergistic effects. This phenomenon needs to be further investigated.
Norio Sugawara; Takashi Ohba; Kunihiko Nakai; Akiyoshi Kakita; Tomoyuki Nakamura; Keita Suzuki; Satomi Kameo; Miyuki Shimada; Naoyuki Kurokawa; Chieko Satoh; Hiroshi Satoh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-09
Journal Detail:
Title:  Archives of toxicology     Volume:  82     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-27     Completed Date:  2008-08-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  387-97     Citation Subset:  IM    
Environmental Health Sciences, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
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MeSH Terms
Behavior, Animal / drug effects*
Body Weight / drug effects
Chlorodiphenyl (54% Chlorine) / toxicity*
Conditioning, Operant / drug effects
Drug Interactions
Drug Therapy, Combination
Environmental Pollutants / toxicity*
Eye / drug effects,  growth & development
Lactation / drug effects
Litter Size / drug effects
Maternal Exposure / adverse effects*
Maze Learning / drug effects
Methylmercury Compounds / toxicity*
Mice, Inbred C57BL
Motor Activity / drug effects
Nervous System / drug effects*,  embryology,  growth & development
Prenatal Exposure Delayed Effects
Reg. No./Substance:
0/Environmental Pollutants; 0/Methylmercury Compounds; 11097-69-1/Chlorodiphenyl (54% Chlorine)

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