Document Detail


Effects of peridural block: V. Properties, circulatory effects, and blood levels of etidocaine and lidocaine.
MedLine Citation:
PMID:  235229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ten healthy, unpremedicated, male volunteers, aged 21-33 years, were given 20 ml 1 per cent etidocaine with 5 mug/ml epinephrine for peridural analgesia via a catheter placed L2. On a different occasion they were given 20 ml 2 per cent lidocaine with 5 mug/ml epinephrine in the same manner. Initial onset of sensory analgesia to pin prick was faster for etidocaine (7 min) than for lidocaine (9 min). Analgesia lasted significantly longer after etidocaine with respect to both two-segment regression (177 plus or minus SE min vs. 114 plus or minus 8 min) and total duration (379 plus or minus 22 min vs. 190 plus or minus 8 min). Onset of maximal motor blockade was significantly faster with etidocaine (15.4 plus or minus 2.5 min) than with lidocaine (31.7 plus or minus 3.3 min); blockade lasted longer with etidocaine (331 plus or minus 25 min vs. 167 plus or minus 13 min). Changes in mean arterial pressure cardiac output, central venous pressure, limb blood flows, total peripheral resistance, and stroke volume were similar with the two drugs, although those after etidocaine were more prolonged as a result of the longer blockade. Mean maximum arterial concentrations of etidocaine were 0.96 plus or minus 0.05 SE mug/ml (plasma) and 0.55 plus or minus 0.03 mug/ml (whold blood), achieved at 17 plus or minus 2 min. Mean maximum arterial concentrations of lidocaine were 2.22 plus or minus 0.09 mug/ml (plasma) and 1.85 plus or minus mug/ml (whold blood), achieved at 24 plus or minus 2 min. No sign of central toxicity was observed with either drug, although subjects receiving lidocaine tended to sleep, which was not the case with etidocaine. Hematologic screening, blood chemistries, and urinalyses performed 24 hours before and after each study showed no abnormality.
Authors:
M Stanton-Hicks; T M Murphy; J J Bonica; P U Berges; L E Mather; G T Tucker
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  42     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-05-27     Completed Date:  1975-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  398-407     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acetanilides / analogs & derivatives,  pharmacology
Adult
Analgesia
Anesthesia, Epidural*
Anesthetics, Local / blood,  pharmacology*
Arm / blood supply
Blood
Blood Pressure / drug effects
Carbon Dioxide / blood
Cardiac Output / drug effects
Central Venous Pressure / drug effects
Epinephrine
Ethylamines / pharmacology
Galvanic Skin Response / drug effects
Humans
Hydrogen-Ion Concentration
Leg / blood supply
Lidocaine / blood,  pharmacology
Male
Motor Activity / drug effects
Propylamines / pharmacology
Regional Blood Flow / drug effects
Sympathetic Nervous System / drug effects
Time Factors
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Acetanilides; 0/Anesthetics, Local; 0/Ethylamines; 0/Propylamines; 124-38-9/Carbon Dioxide; 137-58-6/Lidocaine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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