| Effects of perfluorinated amphiphiles on backward swimming in Paramecium caudatum. | |
| | |
MedLine Citation:
|
PMID: 16300727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PFOS and PFOA are ubiquitous contaminants in the environment. We investigated the effects of fluorochemicals on calcium currents in Paramecium caudatum using its behavioral changes. Negatively charged amphiphiles prolonged backward swimming (BWS) of Paramecium. PFOS significantly prolonged BWS, while PFOA was less potent (EC(50): 29.8+/-4.1 and 424.1+/-124.0microM, respectively). The BWS prolongation was blocked by cadmium, indicating that the cellular calcium conductance had been modified. The positively charged amphiphile FOSAPrTMA shortened BWS (EC(50): 19.1+/-17.3). Nonionic amphiphiles did not affect BWS. The longer-chain perfluorinated carboxylates PFNA and PFDA were more potent than PFOA (EC(50): 98.7+/-20.1 and 60.4+/-10.1microM, respectively). However, 1,8-perfluorooctanedioic acid and 1,10-perfluorodecanedioic acid did not prolong BWS. The critical micelle concentration (CMC) and BWS prolongation for negatively charged amphiphiles showed a clear correlation (r(2)=0.8008, p<0.001). In summary, several perfluorochemicals and PFOS and PFOA had similar effects in Paramecium, while chain length, CMC, and electric charge were major determinants of BWS duration. |
| | |
Authors:
|
Eriko Matsubara; Kouji Harada; Kayoko Inoue; Akio Koizumi |
Related Documents
:
|
16141527 - Anxiolytic-like effects of ginsenosides on the elevated plus-maze model in mice. 21284097 - Pulmonary outcome of alport syndrome with familial diffuse esophageal leiomymatosis. 22499417 - Nephrotic syndrome associated with toxoplasmosis: report of seven cases. 22535007 - Bruns' syndrome and racemose neurocysticercosis: a case report. 11960817 - Genetics of familial episodic vertigo and ataxia. 11042557 - Frey syndrome: treatment with type a botulinum toxin. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-11-16 |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: 339 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2005-12-07 Completed Date: 2006-02-07 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
|
Languages: eng Pagination: 554-61 Citation Subset: IM |
Affiliation:
|
Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068501, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alkanesulfonic Acids
/
chemistry,
pharmacology* Animals Cadmium / pharmacology Carbon / chemistry Fluorine / chemistry* Fluorocarbons / chemistry, pharmacology* Molecular Structure Nifedipine / pharmacology Octanoic Acids / chemistry, pharmacology* Paramecium caudatum / drug effects*, physiology* Structure-Activity Relationship Swimming / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Alkanesulfonic Acids; 0/Fluorocarbons; 0/Octanoic Acids; 1763-23-1/perfluorooctane sulfonic acid; 21829-25-4/Nifedipine; 335-67-1/perfluorooctanoic acid; 7440-43-9/Cadmium; 7440-44-0/Carbon; 7782-41-4/Fluorine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phthalocyanine-mediated photodynamic therapy induces cell death and a G0/G1 cell cycle arrest in cer...
Next Document: Induction of COX-2 protein expression by vanadate in A549 human lung carcinoma cell line through EGF...